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Safety and Efficacy

Drug ĺ ȿ 帳ϴ.

Eurofins Discovery



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  • ๰ ȿ մϴ.
  • off-target related adverse drug reactions (ADRs) ⿡ ĺϿ unsafe compounds Žϰų better drug ϴµ մϴ.
  • GPCR, Ion channel, Transporter, Kinase پ family target ũ մϴ.
  • ܰ躰 Tier 1, 2, 3 شϴ panel մϴ.




FAMILY Service Spectrum
Screen
BioPrint Safety
Screen87
Safety
Screen Functional 
Safety
Screen 44
Cat. No. PP16 P22-p  PP223 P347 PP241
No. of Targets 174 132 87 64 44
Cell Surface  GHB 
Cell Surface IL-6 Human
Cell Surface  Interleukin IL-1 R1
Cell Surface  TNF-alpha
Cytosolic QR2 / MT3
Cytoskeleton Tubulin 
GPCR 5-HT1A √*
GPCR 5-HT1B  √*
GPCR 5-HT1D
GPCR 5-HT2A √*
GPCR 5-HT2B  √*
GPCR 5-HT2C 
GPCR 5-HT3A
GPCR 5-HT4 
GPCR 5-HT5A 
GPCR 5-HT6 
GPCR 5-HT7 
GPCR A1 
GPCR A2A  √*
GPCR A2B 
GPCR A3 
GPCR alpha1A  √*
GPCR alpha1B 
GPCR alpha1D 
GPCR alpha2A √*
GPCR alpha2B 
GPCR alpha2C 
GPCR APJ 
GPCR AT1 
GPCR AT2 
GPCR B1 
GPCR B2 
GPCR BB1 
GPCR BB2
GPCR BB3 
GPCR beta1 √*
GPCR beta2  √*
GPCR beta3 
GPCR BLT1 (LTB4)
GPCR CB1  √*
GPCR CB2  √*
GPCR CCK1 (CCKA)  √*
GPCR CCK2 (CCKB) 
GPCR CCR1 
GPCR CCR2 
GPCR CCR5 
GPCR CGRP (CLR/RAMP1)
GPCR CRF1 
GPCR CT 
GPCR CX3CR1 
GPCR CXCR1 (IL-8RA) 
GPCR CXCR2 (IL-8RB) 
GPCR CXCR3 
GPCR CXCR4 
GPCR CysLT1 
GPCR CysLT2 
GPCR D1  √*
GPCR D2L √*
GPCR D2S 
GPCR D3 
GPCR D4
GPCR D5 
GPCR delta (DOP)  √*
GPCR DP1
GPCR DP2
GPCR EP1
GPCR EP2
GPCR EP3
GPCR EP4
GPCR ETA √*
GPCR ETB
GPCR FP
GPCR GABAB (B1a/B2)
GPCR GABAB (B1b/B2)
GPCR GHSR
GPCR Glucagon
GPCR GnRH
GPCR H1 √*
GPCR H2 √*
GPCR H3
GPCR H4R
GPCR IP
GPCR kappa (KOP) √*
GPCR M1 √*
GPCR M2 √*
GPCR M3 √*
GPCR M4
GPCR M5
GPCR MC1
GPCR MC3
GPCR MC4
GPCR MC5
GPCR MCH1
GPCR mGlu2
GPCR mGlu5
GPCR Motilin
GPCR MT1
GPCR MT2
GPCR mu (MOP) √*
GPCR NK1
GPCR NK2
GPCR NK3
GPCR Acetylcholine (Muscarinic), Non-Selective
GPCR P2Y, Non-Selective
GPCR NOP (ORL1)
GPCR NT1
GPCR OT
GPCR OX1
GPCR OX2
GPCR PAF
GPCR sst1
GPCR sst2
GPCR sst3
GPCR sst4
GPCR sst5
GPCR TRH
GPCR UT (GPR14)
GPCR V1A √*
GPCR V1B
GPCR V2
GPCR VIP1 (VPAC1)
GPCR VIP2 (VPAC2)
GPCR Y1
GPCR Y2
Ion Channel 5-HT3A
Ion Channel Cav1.2 (L-type) (Dihydropyridine Site)
Ion Channel Cav1.2 (L-type) (Diltiazem Site)
Ion Channel Cav1.2 (L-type) (Verapamil Site)
Ion Channel Cav1.2 (L-type)
Ion Channel Cav2.2 (N-type)
Ion Channel Glutamate (AMPA, Non-Selective)
Ion Channel Glutamate (Kainate, Non-Selective) 
Ion Channel Glutamate (NMDA, Non-Selective) CGP-39653
Ion Channel Glutamate (NMDA, Non-Selective) Ifenprodil
Ion Channel Glutamate (Non-Selective) TCP
Ion Channel Glutamate, NMDA, MDL 105,519
Ion Channel hERG
Ion Channel IP3R1
Ion Channel KATP
Ion Channel KCNQ1
Ion Channel KV (Non-Selective) 
Ion Channel nAChR (alpha1) 
Ion Channel nAChR (alpha3/beta4) 
Ion Channel nAChR (alpha4/beta2) 
Ion Channel nAChR (alpha7) Human
Ion Channel nAChR (alpha7) Rat
Ion Channel nAChR (Muscle-Type) 
Ion Channel Nav1.5
Ion Channel GABAA (alpha1/beta2/gamma2) 
Ion Channel GABAA [3H] , Non-Selective
Ion Channel GABAA [3H] Muscimol, Non-Selective
Ion Channel GABAA [3H] TBOB, Non-Selective
Ion Channel GABAA, [3H] Flunitrazepam  
Ion Channel GABAA, [3H] Ro-15-1788
Ion Channel Glycine [3H] Strychnine, Non-Selective
Ion Channel P2X, Non-Selective
Ion Channel Sodium Ion Channel [3H],Non-Selective, Batrachotoxinin
Ion Channel Gabapentin
Ion Channel RY3
Ion Channel SKCa (Non-Selective)
Kinase Abl
Kinase CaMK2alpha
Kinase CDK2 / cyclinA
Kinase EGFR
Kinase ERK2 (MAPK1)
Kinase Flt-1 (VEGFR1)
Kinase Fyn
Kinase IR
Kinase lck
Kinase LYN
Kinase PKCalpha
Kinase PDGFR (Non-Selective) 
Kinase SAPK2A (p38alpha)
Kinase TGFbeta (Non-Selective) 
Kinase ZAP70
Lipid Metabolism COX1
Lipid Metabolism COX2
Nitrogen Metabolism iNOS
NHR AR
NHR ERalpha
NHR ERbeta
NHR GR
NHR LXRbeta
NHR MCR
NHR PPARgamma
NHR PR
NHR RARalpha
NHR RXRalpha
NHR TR (Non-Selective) 
NHR VDR
Nucleotide Signaling Atrial Natriuretic Factor (ANF, Non-Selective) 
Nucleotide Signaling Guanylyl Cyclase
Neurotransmitter Metabolism Acetylcholinesterase
Neurotransmitter Metabolism Monoamine Oxidase A (MAO-A)
Neurotransmitter Metabolism Monoamine Oxidase B (MAO-B)
Other Phorbol Ester 
PDE PDE2A
PDE PDE3A
PDE PDE3B
PDE PDE4D
PDE PDE5
PDE PDE6
PDE Rolipram 
Protease ACE
Protease ACE2
Protease beta-Secretase 1
Protease Caspase 3
Protease Cathepsin G
Protease HIV-1
Protease MMP1
Protease MMP2
Protease MMP9
Steroid Metabolism Xanthine Oxidase
Transmembrane Imidazoline I2
Transmembrane sigma1 
Transmembrane  sigma2 
Transporter Adenosine 
Transporter ATPase
Transporter CHT1 
Transporter DAT
Transporter GABA (Non-Selective) 
Transporter GLYT1 
Transporter NET 
Transporter SET
Transporter VMAT (Non-Selective) 

   *cell-based Ÿ agonist &antagonist





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