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 ǰȳ  ڻ   COVID-19 Research

[COVID-19] SARS-Cov-2 Compound Repurposing

SARS-CoV homology 80% ġϴ COVID-19, ֱ human mucosal ǥ ACE2 virus ǥ spike binding Ǿ virus ּ յǴ mechanism ̷ mechanism antiviral ๰ ġḦ target ˷ , COVID-19 ȯ ׿ 鿪 Ͽϴ.

Ȯε compound COVID-19 ִ ๰ ȳ帳ϴ.

TOCRIS
ǰ ϱ
μϱ

Cat. No. Product Name / Activity
6960 ABT 199
Exhibits binding to SARS-CoV-2 3CLpro in a virtual screen; selective and high affinity Bcl-2 inhibitor;
4274 AP 24534
Identified as targeting human proteins in the SARS-CoV-2 interactome; potent multi-kinase and pan-Bcr-Abl inhibitor
4139 Aprotinin
Inhibits SARS-CoV-2 infection in vitro; serine protease inhibitor
6358 Atovaquone
Exhibits anti-MERS-CoV activity in vitro; DHODH inhibitor
3771 Azithromycin
Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.
3193 Camostat mesylate
Inhibits entry of SARS-Cov-2 into lung cells; protease inhibitor
4455 Captopril
Targets human proteins in the SARS-CoV-2 interactome; ACE inhibitor
4109 Chloroquine diphosphate
Inhibits SARS-CoV-2 infection in vitro
6357 Ciclesonide
Inhibits replication fo SARS-CoV-2 in vitro; glucocorticoid
1364 Colchicine
Identified as a candidate for repurposing for COVID-19
0970 Cycloheximide
Exhibits anti-MERS-CoV activity in vitro; protein synthesis inhibitor
1101 Cyclosporin A
Inhibits coronavirus replication; cyclophilin inhibitor
6710 Darunavir
Predicted to bind PLpro of SARS-CoV-2; potent HIV protease inhibitor
6793 Dasatinib
Inhibits replication of SARS-CoV and MERS-CoV in vitro
1467 Daunorubicin hydrochloride
Identified as targeting human proteins in the SARS-CoV-2 interactome; DNA topoisomerase II inhibitor
4583 Digoxin
Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
3807 Disulfiram
SARS-Co-2 Mpro inhibitor; also reversibly stimulates SERCA Ca2+-ATPase
3631 FK 506
Identified as targeting human proteins in the SARS-CoV-2 interactome; potent calcineurin inhibitor
3259 Gemcitabine hydrochloride
Inhibits replication of coronaviruses; DNA synthesis inhibitor
0931 Haloperidol hydrochloride
Targets human proteins in the SARS-CoV-2 interactome
5648 Hydroxychloroquine sulfate
Inhibits SARS-CoV-2 viral infection in vitro
5906 Imatinib mesylate
Inhibits replication of SARS-CoV and MERS-CoV in vitro; potent and selective v-Abl tyrosine kinase inhibitor
1708 Indomethacin
Identified as targeting human proteins in the SARS-CoV-2 interactome
1260 Ivermectin
Inhibits replication of SARS-Cov-2 in vitro; antiparasitic and antiviral
2959 Lercanidipine hydrochloride
Exhibits anti-MERS-CoV activity in vitro; CaV1.x blocker
3765 Linezolid
Identified as targeting human proteins in the SARS-CoV-2 interactome; antibiotic
0840 Loperamide hydrochloride
Inhibits replication of coronaviruses in vitro; peripherally acting μ opioid agonist and Ca2+ channel blocker
3798 Losartan potassium
Reduces lung injury in a mouse model of SARS-CoV infection; Selective AT1 antagonist
6819 Mefloquine hydrochloride
Exhibits antiviral activities against SARS-CoV-2; also Cx36 and Cx50 gap channel blocker
2864 Metformin hydrochloride
Identified as targeting human proteins in the SARS-CoV-2 interactome
3081 Nafamostat mesylate
Inhibits SARS-CoV-2 infection in vitro; serine protease inhibitor
3766 Nelfinavir mesylate
Exhibits anti-MERS-CoV activity in vitro; potent HIV-1 protease inhibitor
2583 Omeprazole
Enhances anti-SARS-CoV-2 activity of serine protease inhibitors
1076 Ouabain
Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
2992 PKC 412
Identified as targeting human proteins in the SARS-CoV-2 interactome
1292 Rapamycin
Inhibits MERS-CoV infection; mTOR inhibitor and immunosuppressant
4501 Ribavirin
Inhibits cytopathic effect of SARS-CoV in vitro; guanosine analog and IMPDH inhibitor
5856 Ritonavir
Improves outcome in an animal model of MERS-CoV infection; HIV protease inhibitor
7064 Ruxolitinib New
Targets human proteins in the SARS-CoV-2 interactome; potent and selective JAK1/JAK2 inhibitor
4418 Saquinavir mesylate
Modeling predicts inhibitor action at SARS-CoV-2 3CLpro; HIV protease inhibitor
3784 Sildenafil citrate
Reduces pulmonary pressure and edema; potent PDE5 inhibitor; orally active
0652 Thalidomide
Predicted to reduce cytokine release in SARS-CoV-2 infection; inhibits synthesis of TNF-α
2815 Valproic acid, sodium salt
Identified as targeting human proteins in the SARS-CoV-2 interactome
0654 Verapamil hydrochloride
Targets human proteins in the SARS-CoV-2 interactome; CaV1.x blocker

 

 ACE Small Molecule Compound
Cat.No. Product Description
2578 Benazepril hydrochloride ACE inhibitor
4302 Perindopril erbumine ACE inhibitor
4455 Captopril ACE inhibitor also inhibits LTA4 hydrolase
 Cathepsin B/L Small Molecule Compounds
Cat.No. Product Description
0448 Calpeptin Calpain and cathepsin L inhibitor
3625 SID 26681509 Cathepsin L inhibitor
4863 CA 074 Selective cathepsin B inhibitor
0384 N-Acetyl-L-leucyl-
L-leucyl-L-methional
Cathepsin inhibitor
4545 E 64d Cathepsin inhibitor; interferes with autolysosomal digestion
1146 MDL 28170 Potent and selective Calpain and Cathepsin B inhibitor 
 IL-1 beta Small Molecule Compound
Cat.No. Product Description
1793 AF 12198 potent, selective human type IL-1 receptor antagonist
 TNF-alpha Small Molecule Compound
Cat.No. Product Description
5484 C 87 TNF-α inhibitor
 VEGFR-2 Small Molecule Compounds
Cat.No. Product Description
3882 (E)-FeCP-oxindole Selective VEGFR-2 inhibitor
2542 Ki 8751 potent, selective VEGFR-2 inhibitor
 Aminopeptidase Small Molecule Compounds
Cat.No. Product Description
3595 CHR 2797 Aminopeptidase inhibitor, also called Tosedostat
 DPPIV/CD26 Small Molecule Compounds
Cat.No. Product Description
2783 DPPI 1c DPPIV/CD26 inhibitor
2790 K 579 DPPIV/CD26 inhibitor
3506 NVP DPP 728 Potent DPPIV/CD26 inhibitor; orally active
6507 Saxagliptin High affinity DPPIV/CD26 inhibitor; active in vivo
 Human Neutrophil Elastase 1 (HNE1) Small Molecule Compounds
Cat.No. Product Description
5651 ONO 6818 High affinity and selective Human Neutrophil Elastase 1 (HNE1) inhibitor; orally active
5706 BAY 678 Potent Human Neutrophil Elastase (HNE) inhibitor;
cell permeable
6389 BAY 677 Inactive control for BAY 678 (Catalog # 5706)
 Furin Small Molecule Compounds
Cat.No. Product Description
1793 AF 12198 Potent Furin inhibitor
 TMPRSS2 Small Molecule Compounds
Cat.No. Product Description
3193 Camostat TMPRSS2 inhibitor
3081

Nafamostat

Inhibits SARS-CoV-2 infection in vitro
 Autophagy Small Molecule Compounds
Cat.No. Product Description
5648 Hydroxychloroquine sulfate   Autophagy inhibitor, also inhibits TLR9; inhibits SARS-CoV-2 viral infection
 Topo I inhibitor
Cat. No. product size
TG4100 Topotecan Hydrochloride
(Hycamtin)
0.25 mL
TG4101 Irinotecan (CPT-11) 0.25 mL
TG4110 Camptothecin 0.25 mL
 Topo II inhibitor
Cat. No. product size
TG4140 Etoposide (VP16) 0.25 mL
  There is current research linking the inhibition of topoisomerase and the "cytokine storm"  that follows SAR CoV2 infections (COVID-19).

 

   Drug Repurposing (๰â) : Tocriscreen Compound Library
ֹ(Ordering Information)
CATNUM PRODUCT SIZE
3882(E)-FeCp-oxdole10mg
6960ABT 19910 mg
6960ABT 19950 mg
1793AF 12198 1mg
4274AP 2453450 mg
4274AP 2453410 mg
4139Aprotinin10 mg
6358Atovaquone10 mg
6358Atovaquone50 mg
3771Azithromycin50mg
6389BAY 6775 mg
5706BAY 6785 mg
2578Benazepril hydrochloride 50mg
5484C 8710 mg
4863CA 0741 mg
0448Calpeptin 10mg
3193Camostat mesylate10mg
TG4110Camptothecin 10mM0.25ml
4455Captopril50 mg
4109Chloroquine diphosphate50 mg
3595CHR 27971mg
6357Ciclesonide25 mg
6357Ciclesonide5 mg
1364Colchicine 1g
0970Cycloheximide 100mg
1101Cyclosporin A 100mg
6710Darunavir 50 mg
6710Darunavir 10 mg
6793Dasatinib100 mg
1467Daunorubicin hydrochloride 10mg
4583Digoxin50 mg
3807Disulfiram50 mg
2783DPPI 1c hydrochloride1mg
4545E 64d (1 MG)1 mg
TG4140Etoposide 10mM0.25ml
3631FK 50610mg
3259Gemcitabine hydrochloride10mg
3259Gemcitabine hydrochloride50mg
0931Haloperidol hydrochloride 100mg
5648Hydroxychloroquine sulfate10 mg
5906Imatinib mesylate100 mg
1708Indomethacin 100mg
TG4101Irinotecan 10mM0.25ml
1260Ivermectin 100mg
2790K 57910mg
2542Ki 875110mg
2959Lercanidipine hydrochloride10mg
2959Lercanidipine hydrochloride50mg
3765Linezolid10mg
0840Loperamide hydrochloride 1g
3798Losartan potassium50mg
1146MDL 2817010mg
6819Mefloquine hydrochloride50 mg
2864Metformin hydrochloride100mg
0384N-Acetyl-L-leucyl-L-leucyl-L-methional 10mg
3081Nafamostat mesylate10mg
3081Nafamostat mesylate50mg
3766Nelfinavir mesylate10mg
3766Nelfinavir mesylate50mg
3506NVP DPP 728 dihydrochloride10mg
2583Omeprazole 50mg
5651ONO 681810 mg
1076Ouabain 100mg
4302Perindopril erbumine50mg
2992PKC 4121mg
1292Rapamycin 1mg
4501Ribavirin50mg
5856Ritonavir50 mg
7064Ruxolitinib50 mg
4418Saquinavir mesylate50mg
4418Saquinavir mesylate10mg
6507Saxagliptin hydrochloride10 mg
3625SID 2668150910mg
3784Sildenafil citrate10mg
3784Sildenafil citrate50mg
0652Thalidomide 100mg
TG4100Topotecan 10mM0.25ml
2815Valproic acid, sodium salt100mg
0654Verapamil hydrochloride 1g