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 제품안내  맞춤 서비스   Drug Discovery Service

Kinases Screening & Profiling 서비스

개발하신 Kinase inhibitor, New drug(compound)를 원하시는 kinase, phosphatase 및 패널을 대상으로 스크리닝하여 inhibition activity와 IC50를 구해드립니다.

Eurofins
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특징
  • Upstate, Millipore부터 이어온 15년 이상의 기술력과 노하우를 바탕으로 신뢰성있는 결과를 제공합니다. 
  • 화합물이 연구소에 도착 후, 1주 이내 보장으로 신속하게 데이터를 받아보실 수 있습니다.
  • 엄격한 QC를 통해 반복실험간의 variation이 매우 낮습니다.
  • ATP의 사용으로 substrate가 active site에 반응하도록 환경을 만든 뒤, inhibitor의 효과를 확인하는 Functional assay로 정확하고 효과적입니다.
  • 조건을 set up하기 위한 시간과 노력을 절약하실 수 있으며, 필요한 enzyme과 시약을 모두 구입하지 않아도 되므로 경제적입니다.
  • 각 질병과 kinase family로 구성된 Panel service를 이용하여 스크리닝 하시면 편리합니다. 
  • Standard한 방법 외에도 non-standard solvents 혹은 pre-incubation등을 Flexibile assay도 제공합니다.


서비스서비스 기간서비스 내용
KinaseProfiler 1주 Kinase panel에 소개된 kinase를 대상으로, 원하는 Kinase에 대한 테스트 제공
IC50 Profiler Express 1주 원하는 Kinase에 대하여 IC50 값 측정



  • 총 423가지 kinase/phosphatase
  AAK1(h) FGFR4(h) PI3 Kinase(p110α(E542K/p85α)(m)
  Abl(h) Fgr(h) PI3 Kinase(p110α(E545K)/p85α)(h)
  Abl(H396P)(h) Flt1(h) PI3 Kinase(p110α(E545K)/p85α)(m)
  Abl(m) Flt3(D835Y)(h) PI3 Kinase(p110α(H1047R)/p85α)(h)
  Abl(M351T)(h) Flt3(h) PI3 Kinase(p110α(H1047R)/p85α)(m)
  Abl(Q252H)(h) Flt4(h) PI3 Kinase(p110α/p65α)(h)
  Abl(T315I)(h) Fms(h) PI3 Kinase(p110α/p65α)(m)
  Abl(Y253F)(h) Fms(Y969C)(h) PI3 Kinase(p110α/p85α)(h)
  ACK1(h) Fyn(h) PI3 Kinase(p110α/p85α)(m)
  ACTR2(h) GCK(h) PI3 Kinase(p110β/p85α)(h)
  ALK(h) GCN2(h) PI3 Kinase(p110β/p85α)(m)
  ALK1(h) GRK1(h) PI3 Kinase(p110β/p85β)(m)
  ALK2(h) GRK2(h) PI3 Kinase(p110δ/p85α)(h)
  ALK4(h) GRK3(h) PI3 Kinase(p110δ/p85α)(m)
  ALK6(h) GRK5(h) PI3 Kinase(p120γ)(h)
  AMPKα1(h) GRK6(h) PI3KC2α(h)
  AMPKα2(h) GRK7(h) PI3KC2γ(h)
  A-Raf(h) GSK3α(h) Pim-1(h)
  Arg(h) GSK3β(h) Pim-2(h)
  Arg(m) haspin(h) Pim-3(h)
  ARK5(h) Hck activated(h) PIP4K2α(h)
  ASK1(h) Hck(h) PIP5K1α(h)
  ATM(h) HIPK1(h) PIP5K1γ(h)
  ATR/ATRIP(h) HIPK2(h) PKA(h)
  Aurora-A(h) HIPK3(h) PKAcb(h)
  Aurora-B(h) HIPK4(h) PKBα(h)
  Aurora-C(h) HPK1(h) PKBβ(h)
  Axl(h) HRI(h) PKBγ(h)
  BIKe(h) ICK(h) PKCα(h)
  Blk(h) IGF-1R activated(h) PKCβI(h)
  Blk(m) IGF-1R(h) PKCβII(h)
  BMPR2(h) IKKα(h) PKCγ(h)
  Bmx(h) IKKβ(h) PKCδ(h)
  B-Raf(h) IKKε(h) PKCε(h)
  B-Raf(V599E)(h) IR activated(h) PKCζ(h)
  BRK(h) IR(h) PKCη(h)
  BrSK1(h) IRAK1(h) PKCθ(h)
  BrSK2(h) IRAK4(h) PKCι(h)
  BTK(h) IRE1(h) PKCμ(h)
  BTK(R28H)(h) IRR(h) PKD2(h)
  CaMKI(h) Itk(h) PKD3(h)
  CaMKIb(h) JAK1(h) PKG1α(h)
  CaMKIIα(h) JAK2(h) PKG1β(h)
  CaMKIIβ(h) JAK3(h) PKR(h)
  CaMKIIγ(h) JNK1α1(h) Plk1(h)
  CaMKIIδ(h) JNK2α2(h) Plk3(h)
  CaMKIV(h) JNK3(h) Plk4(h)
  CaMKIγ(h) KDR(h) PRAK(h)
  CaMKIδ(h) Lck activated(h) PRK1(h)
  CaMKK1(h) Lck(h) PRK2(h)
  CaMKK2(h) LIMK1(h) PRKG2(h)
  Cdc7/cyclinB1(h) LIMK2(h) PrKX(h)
  CDK1/cyclinB(h) LKB1(h) PRP4(h)
  CDK12/cyclinK(h) LOK(h) PTK5(h)
  CDK13/cyclinK(h) LRRK2(h) Pyk2(h)
  CDK14/cyclinY(h) LTK(h) Ret(h)
  CDK16/cyclinY(h) Lyn(h) Ret(V804L)(h)
  CDK17/cyclinY(h) Lyn(m) Ret(V804M)(h)
  CDK18/cyclinY(h) MAK(h) RIPK1(h)
  CDK2/cyclinA(h) MAP4K3(h) RIPK2(h)
  CDK2/cyclinE(h) MAP4K4(h) ROCK-I(h)
  CDK3/cyclinE(h) MAP4K5(h) ROCK-II(h)
  CDK4/cyclinD3(h) MAPK1(h) ROCK-II(r)
  CDK5/p25(h) MAPK2(h) Ron(h)
  CDK5/p35(h) MAPK2(m) Ros(h)
  CDK6/cyclinD3(h) MAPKAP-K2(h) Rse(h)
  CDK7/cyclinH/MAT1(h) MAPKAP-K3(h) Rsk1(h)
  CDK9/cyclinT1(h) MARK1(h) Rsk1(r)
  CDKL1(h) MARK3(h) Rsk2(h)
  CDKL2(h) MARK4(h) Rsk3(h)
  CDKL3(h) MEK1 (h) Rsk4(h)
  CDKL4(h) MEK2(h) SAPK2a(h)
  ChaK1(h) MEKK2(h) SAPK2a(T106M)(h)
  CHK1(h) MEKK3(h) SAPK2b(h)
  CHK2(h) MELK(h) SAPK3(h)
  CHK2(I157T)(h) Mer(h) SAPK4(h)
  CHK2(R145W)(h) Met(D1246H)(h) SBK1(h)
  CK1(y) Met(D1246N)(h) SGK(h)
  CK1γ1(h) Met(h) SGK2(h)
  CK1γ2(h) Met(M1268T)(h) SGK3(h)
  CK1γ3(h) Met(Y1248C)(h) SIK(h)
  CK1δ(h) Met(Y1248D)(h) SIK2(h)
  CK1ε(h) Met(Y1248H)(h) SIK3(h)
  CK2(h) MINK(h) SLK(h)
  CK2α1(h) MKK3(h) Snk(h)
  CK2α2(h) MKK4(m) SNRK(h)
  c-Kit (V654A)(h) MKK6(h) Src(1-530)(h)
  c-Kit(D816H)(h) MKK7β(h) Src(T341M)(h)
  c-Kit(D816V)(h) MLCK(h) SRMS(h)
  c-Kit(h) MLK1(h) SRPK1(h)
  c-Kit(V560G)(h) MLK2(h) SRPK2(h)
  CLIK1(h) MLK3(h) STK16(h)
  CLK1(h) Mnk2(h) STK25(h)
  CLK2(h) MOK(h) STK32A(h)
  CLK3(h) MRCKα(h) STK32B(h)
  CLK4(h) MRCKβ(h) STK32C(h)
  c-RAF(h) MRCKγ(h) STK33(h)
  CRIK(h) MSK1(h) Syk(h)
  CSK(h) MSK2(h) TAF1L(h)
  cSRC(h) MSSK1(h) TAK1(h)
  DAPK1(h) MST1(h) TAO1(h)
  DAPK2(h) MST2(h) TAO2(h)
  DCAMKL2(h) MST3(h) TAO3(h)
  DCAMKL3(h) MST4(h) TBK1(h)
  DDR1(h) mTOR(h) Tec activated(h)
  DDR2(h) mTOR/FKBP12(h) TGFBR1(h)
  DMPK(h) MuSK(h) TGFBR2(h)
  DNA-PK(h) MYLK2(h) Tie2(h)
  DRAK1(h) MYO3B(h) Tie2(R849W)(h)
  DRAK2(h) NDR2(h) Tie2(Y897S)(h)
  DYRK1A(h) NEK1(h) TLK1(h)
  DYRK1B(h) NEK11(h) TLK2(h)
  DYRK2(h) NEK2(h) TNIK(h)
  DYRK3(h) NEK3(h) TRB2(h)
  eEF-2K(h) NEK4(h) TrkA(h)
  EGFR(h) NEK6(h) TrkB(h)
  EGFR(L858R)(h) NEK7(h) TrkC(h)
  EGFR(L861Q)(h) NEK9(h) TSSK1(h)
  EGFR(T790M)(h) NIM1(h) TSSK2(h)
  EGFR(T790M, L858R)(h) NLK(h) TSSK3(h)
  EphA1(h) NUAK2(h) TSSK4(h)
  EphA2(h) p70S6K(h) TTBK1(h)
  EphA3(h) PAK1(h) TTBK2(h)
  EphA4(h) PAK2(h) TTK(h)
  EphA5(h) PAK3(h) Txk(h)
  EphA7(h) PAK4(h) TYK2(h)
  EphA8(h) PAK5(h) ULK1(h)
  EphB1(h) PAK6(h) ULK2(h)
  EphB2(h) PAR-1Bα(h) ULK3(h)
  EphB3(h) PASK(h) VRK1(h)
  EphB4(h) PDGFRα(D842V)(h) VRK2(h)
  ErbB2(h) PDGFRα(h) Wee1(h)
  ErbB4(h) PDGFRα(V561D)(h) Wee1B(h)
  FAK(h) PDGFRβ(h) WNK1(h)
  Fer(h) PDHK2(h) WNK2(h)
  Fes(h) PDHK4(h) WNK3(h)
  FGFR1(h) PDK1(h) WNK4(h)
  FGFR1(V561M)(h) PEK(h) Yes(h)
  FGFR2(h) PhKγ1(h) ZAK(h)
  FGFR2(N549H)(h) PhKγ2(h) ZAP-70(h)
  FGFR3(h) PI3 Kinase(p110α(E542K)/p85α)(h) ZIPK(h)

 
  •  Kinase, Phosphatase : Scintiation 기계로 방사성동위원소 카운팅

         

  • PI3 Kinase : HTRF 방법 이용 - TR-FRET (time-resolved fluorescence resonance energy transfer)
         



 

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