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 제품안내  맞춤 서비스   Drug Discovery Service

Cardiac Profiler 서비스

고객께서 개발하신 hit or lead compounds의 Cardiac Ion Channel Selectivity Screening 서비스를 제공해 드립니다.
Merck Millipore
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    특징
  • 고객께서 개발한 신약이 심장의 리듬을 조절하는 ion channel에 대해 얼마나 안정한지를 테스트 해드립니다.
  • 밀리포아에서 제작한 PrecisION hERG cell line을 이용하여 실험해 드립니다.
  • 명확하고 정확한 Profiling data를 제공합니다.
  • 샘플 의뢰에서 결과물 확인까지 2주일정도 소요됩니다.
    서비스 방법
  1. 1. 아래의 3가지 조건을 고마에 제공해 주셔야 합니다.
    1. 1) 테스트를 원하는 compound의 갯수
    2. 2) 테스트를 원하는 [compound] 농도수
    3. 3) 테스트를 원하는 hERG Ion channel의 종류
    4. * 테스트 반복횟수는 중복실험을 기본사양으로 합니다.
  2. 2. 고마로부터 견적을 받으신후 compound shipping information과 함께 compound를 고마로 발송합니다.
    시료 보내실곳
  • 주소: (우:157-793) 서울시 강서구 가양3동1487번지 가양테크노타운 301호 고마바이오텍(주)
  • 전화: 02-579-8787, 팩스 : 02-578-7042
  • 이메일문의: koma@komabiotech.co.kr
    CardiacProfiler 종류
    Description Catalogue Number
    hERG CardiacProfiler IW Service CYL6038QU
    In vitro testing of compounds for hERG (IKr) block is an essential component in assessing cardiac risk. Functional assay using automated electrophysiology (IonWorks)
    hERG CardiacProfiler PX Service CYL6039PX
    In vitro testing of compounds for hERG (IKr) block is an essential component in assessing cardiac risk. Functional assay using automated electrophysiology (PatchXpress)
    hKCNQ1/hminK CardiacProfiler Service CYL5007QU
    Potassium channel mediating IKs current that is involved in action potential repolarization in ventricular cardiac myocytes. Functional assay using automated electrophysiology (IonWorks)
    hHCN4 CardiacProfiler Service CYL5012HT
    An ion channel giving rise to the hyperpolarization activated current (Ih) that maintains the resting potential of ventricular cardiac myocytes. Functional assay using automated electrophysiology (IonWorks)
    hKv4.3/hKChIP2 CardiacProfiler Service CYL5069QU
    Potassium channel underlying IKto current that is involved in the early repolarization phase of action potentials in ventricular cardiac myocytes. Functional assay using automated electrophysiology (IonWorks)
    hNav1.5 CardiacProfiler IW Service CYL5004QU
    The sodium channel mediating INa, the current that initiates the cardiac action potential in ventricular myocytes. Functional assay using automated electrophysiology (IonWorks)
    hNav1.5 CardiacProfiler PX Service CYL5004PX
    The sodium channel mediating INa, the current that initiates the cardiac action potential in ventricular myocytes. Functional assay using automated electrophysiology (PatchXpress).
    hKv1.5 CardiacProfiler Service CYL5018QU
    Potassium channel mediating IKur current that is involved in repolarizing action potentials in atrial cardiac myocytes. Functional assay using automated electrophysiology (IonWorks)
    Human L-type Calcium Channel CardiacProfiler Service CYL5051QU
    The calcium channel (Cav1.2) mediating ICa current that maintains the plateau phase of the action potential in ventricular cardiac myocytes. Functional assay using automated electrophysiology (IonWorks)
    hKir2.1 CardiacProfiler Service CYL5032QU
    An ion channel giving rise to a leak activated current that maintains the resting potential of ventricular cardiac myocytes. Functional assay using automated electrophysiology (IonWorks)
    Ion Channel CardiacProfiler Panel Service: CYL9000
    The Ion Channel CardiacProfiler Panel Service is offered as a monthly profiling service that allows for the comprehensive functional assessment of drug candidates against hERG, hKCNQ1/hminK, hKv1.5, hNav1.5, hHCN4, hKv4.3/hKChIP2, Human L-type Calcium and hKir2.1 ion channels. Collectively, these cardiac ion channels play a critical role in the normal functioning of the human heart and were chosen to provide a more thorough assessment of the true cardiac liability of drug candidates. The potential for altered function to cause QT prolongation has been implicated for the majority of these channels by the occurrence of human LQT mutations. The Ion Channel CardiacProfiler Panel Service utilizes eight distinct PrecisION ion channel cell lines corresponding to each of these cardiac ion channels. All of these cell lines were optimized for use on the IonWorks automated patch clamp instrument for this service.