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 제품안내  면역학   Neuroscience  DNA/RNA Damage

DNA/RNA Damage Assay

DNA는 Cellular stress의 주요 타겟으로, 내부외부적 원인에 의해 손상이 되기 쉬우며, 특정염기에 산화가 일어나거나, 염기가 제거되거나 deamination되기도 하며, DNA 가닥에 절단이 생겨 이들이 위험한 mutagen으로 작용하기도 합니다. 이러한 DNA / RNA Damage에 관련된 여러 산물을 측정하는 제품을 소개합니다.

Cell Biolabs
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DNA/RNA Damage Assay Selection Guide
TargetDescriptionSample typeCat. No.
8-hydroyguanosine
(8-OHG)
산화에 의한 RNA 손상의 ubiquitous 마커인 8-OHG를 ELISA방법으로 정량 Cells STA-325
Tissues
Blood
Urine
Cerebrospinal fluid
8-hydroydeoyguanosine
(8-OHdG)
산화에 의한 DNA 손상의 ubiquitous 마커인 8-OHdG를 ELSIA방법으로 정량 Cells STA-320
Tissues
Blood
Urine
Abasic (AP) sites 손상후 복구되지 않은 DNA base AP (apurinic/apyrimidinic) sites를 측정 Cells STA-324
Tissues
BPDE DNA Adduct BPDE DNA Adduct를 ELISA를 이용하여 정량 Cells STA-357
Tissues
Double-strand DNA breaks phospho-histone H2A.X 항체를 이용하여 Double-strand breaks를 면역형광염색법으로 측정 Cells STA-321
Comet Assay Single cell gel electrophoresis assay를 이용하여 comet (혜성) 모양을 형성하는 손상된 DNA를 확인 Cells STA-350/STA-351
(3-well slides 형식)
STA-355
(96-well plate 형식)
UV-Induced DNA Damage Intact cell 또는 Isolated DNA샘플 내에서 Cell UV light에 의해 형성되는 두가지의 UV damaged DNA인 CPD 및 6-4PP를 ELISA 혹은 Immunostaining방법으로 측정 Cells STA-322, STA-323,
STA-326, STA-328
(ELISA 방법)
STA-327, STA-329
(Immunostaining 방법)
Product Citations
STA-320
  • Pialoux, V. et al. (2009). Effects of exposure to intermittent hypoxia on oxidative stress and acute hypoxic ventilatory response in humans. Am. J. Respir. Crit. Care Med. 180:1002-1009.
  • Hasegawa, T. et al. (2009). Suppression of nitrosative and oxidative stress to reduce cardiac allograft vasculopathy. Am.J. Physiol. Hear Circ. Physiol. 296:H1007-H1016.
  • Ksiazek, K. et al. (2008). Impaired response to oxidative stress in senescent cells may lead to acccumulation of DNA damage in mesothelial cells from aged donors. Biochem. and Biophys. Res. Comm. 373:335-339.
  • Rao, M. et al. (2008). Mitochondrial DNA injury and mortality in hemodialysis patients. J. Am. Soc. Nephrol. 20:189-196.
  • Ksiazek, K. et al. (2008). Vulnerability to oxidative stress and differen patterns of senescence in human peritoneal mesothelial cell strains. Am J. Physiol. Regulatory Integrative Comp. Physiol. 296:R374-R382.
주문정보(Ordering Information)
CATNUM PRODUCT SIZE
STA-355OxiSelect™ 96-Well Comet Assay Kit96 assays
STA-355-5OxiSelect™ 96-Well Comet Assay Kit5 x 96 assays
STA-356-5OxiSelect™ 96-Well Comet Assay Slide5 slides
STA-356OxiSelect™ 96-Well Comet Assay Slide1 slide
STA-357OxiSelect™ BPDE DNA Adduct ELISA Kit96 wells
STA-328OxiSelect™ Cellular UV-Induced DNA Damage ELISA Kit (6-4PP)96 wells
STA-326OxiSelect™ Cellular UV-Induced DNA Damage ELISA Kit (CPD)96 wells
STA-326-5OxiSelect™ Cellular UV-Induced DNA Damage ELISA Kit (CPD)5 x 96 assays
STA-329OxiSelect™ Cellular UV-Induced DNA Damage Staining Kit (6-4PP)96 wells
STA-327OxiSelect™ Cellular UV-Induced DNA Damage Staining Kit (CPD)96 wells
STA-354OxiSelect™ Comet Assay Control Cells1 set
STA-351-5OxiSelect™ Comet Assay Kit (3-Well Slides)5 x 75 assays
STA-351OxiSelect™ Comet Assay Kit (3-Well Slides)75 assays
STA-350OxiSelect™ Comet Assay Kit (3-Well Slides)15 assays
STA-353-5OxiSelect™ Comet Assay Slides (3-Well)5 x 25 slides
STA-353OxiSelect™ Comet Assay Slides (3-Well)25 slides
STA-352OxiSelect™ Comet Assay Slides (3-Well)5 slides
STA-321OxiSelect™ DNA Double-Strand Break (DSB) Staining Kit100 assays
STA-320-5OxiSelect™ Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation)5 x 96 assays
STA-320OxiSelect™ Oxidative DNA Damage ELISA Kit (8-OHdG Quantitation)96 Assays
STA-324OxiSelect™ Oxidative DNA Damage ELISA Kit (AP sites) 50 assays
STA-325OxiSelect™ Oxidative RNA Damage ELISA Kit (8-OHG Quantitation)96 assays
STA-322-COxiSelect™ UV-Induced DNA Damage ELISA Combo Kit (CPD / 6-4PP Quantitation)96 wells
STA-323-5OxiSelect™ UV-Induced DNA Damage ELISA Kit (6-4PP Quantitation)5 x 96 assays
STA-323OxiSelect™ UV-Induced DNA Damage ELISA Kit (6-4PP Quantitation)96 wells
STA-322-5OxiSelect™ UV-Induced DNA Damage ELISA Kit (CPD Quantitation)5 x 96 assays
STA-322OxiSelect™ UV-Induced DNA Damage ELISA Kit (CPD Quantitation)96 wells