Featured Neuroscience Antibodies

제품종류
• NeuN (Neuron-Specific Nuclear Protein)
  NeuN antibody는 neuron을 특정하게 인식하여 결합하며, 척추동물의 중추신경계와 말초신경계의 신경세포에 대부분 존재합니다.
  NeuN antibody는 primary culture와 retinoic acid-stimulated P19 cells에서 neuron에 대한 뛰어난 마커이며, 이식된 곳에서 neuron을 동정하는데 유용하게 사용됩니다.
  

  Mouse anti-NeuN, biotin conjugated (Catalog Number MAB377B). Immunolocalization of NeuN (green) and Nestin (red) in trimethyl tin treated mouse brain section 72 hours after treatment. The blue staining is DAPI. The NeuN:biotin conjugated antibody was detected with streptavidin-Alexafluor 488 and the Nestin antibody was detected with a goat-anti-mouse IgG-Alexafluor 594.
  

  Mouse anti-NeuN, Alexa Fluor 488 conjugated (Catalog Number MAB377X). Immunolocalization of NeuN (green) and BrdU (red, Catalog Number MAB3510) in trimethyl tin treated mouse brain section 7 days after treatment. The blue staining is DAPI. The BrdU antibody was detected with a goat-anti-mouse IgG-Alexa Fluor 594. Photo courtesy of Robert Wine, NIEHS.
  

  

  Mouse anti-NeuN (Catalog Number MAB377) and Rabbit anti-Substance P Receptor (Catalog Number AB5060) staining of normal rat hippocampus. NeuN immunoreactivity in green and Substance P Receptor immunoreactivity in red. Photo courtesy of Dr. Robert Sloviter, University of Arizona.

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  MAB377B	NeuN, clone A60, biotin conjugated	500 μg	H, M, R	WB, IC, IH	Mouse	Biotin	Monoclonal Antibody
  MAB377X	NeuN, clone A60, Alexa Fluor®488 conjugated	500 μg	H, M, R	IH	Mouse	AlexaFluor ®488	Monoclonal Antibody
  MAB377	NeuN, clone A60	500 μg	Av, Ch, Ft, H, M, Po, R, Pm, Sal	IF, IP, WB, IC, IH, IH(P)	Mouse	Purified	Monoclonal Antibody

• Synaptophysin
  Synaptophysin은 38kDa의 glycoprotein으로 뇌, 척수, 망막, 내분비 세포의 신경 결합소포 막에 존재합니다.
  Synaptophysin은 정상적인 신경 내분비 세포와 종양 신경 내분비 세포를 동정하는데 유용한 마커로 사용될 수 있습니다.
  

  Mouse anti-Synaptophysin (Catalog Number MAB5258) localization of synaptophysin in rat hippocampus. Photo courtesy of Dr. Robert Sloviter, University of Arizona.
  

  Mouse anti-Synaptophysin (Catalog Number MAB329). Localization of synaptophysin (red) and Myelin Basic Protein (green) in human hippocampus (paraffin-embedded section).

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  MAB368	Synaptophysin	100 μL	Gp, H, Po, R	ELISA, WB, IH(P)	Mouse	Ascites	Monoclonal Antibody
  MAB5258	Synaptophysin, clone SY38	20 μg	Av, B, H, M, R, F	WB, IC, IH	Mouse	Purified	Monoclonal Antibody
  MAB329	Synaptophysin, clone SP15	100 μL	H, Ht, Po, R	ELISA, WB, IH(P)	Mouse	Ascites	Monoclonal Antibody

• APP (Amyloid precursor protein)
  Amyloid precursor protein은 transmembrane에서 보편적으로 발현되는 단백질로, beta-secretase와 gamma-secretase에 의해 연속적으로 cleaved되어 beta-amyloid peptides와 같이 extracellular peptides로 release되어 알츠하이머병에 걸린 사람의 뇌에 퇴적됩니다.
  

  Mouse anti-APP (Catalog Number MAB348) Western blot of endogenous APPs from SH-SY5Y conditioned medium.
  

  Negative Control staining on Alzheimer’s Disease-Hypothalamus. Tissue pretreated with Citrate, pH 6.0. Negative Control Reagent, IHC-Select Detection with HRP-DAB. High mag.
  

  Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  Amyloid Precursor Protein (APP), clone LN27	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  Amyloid Precursor Protein (APP), clone 1G6	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  Amyloid Precursor Protein (APP), clone D3B10	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-8), clone 1E11	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-8), clone 2H4	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid, clone 20.1	0.2 mL	H	IC	Mouse	Purified	Monoclonal Antibody
  Amyloid-β (Aβ), clone NAB 228	0.2 mL	H	WB, IH, ELISA, IP	Mouse	Ascites	Monoclonal Antibody
  β-Amyloid (1-16), clone 6E10	0.2 mL	H	IC	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-16)	0.2 mL	H	WB, IC, ELISA	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid, Rodent Specific	50 ug	Rodent	WB, IC, ELISA	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid (17-24), clone 4G8	0.2 mL	H, R	IC	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-40), clone 11A50-B10	0.2 mL	H, R	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid 40	50 ug	H, R	IC	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid (1-42), clone 12F4	0.2 mL	H, R	0.2 mL	Mouse	Purified	Monoclonal Antibody
  β-Amyloid 42	0.2 mL	H, R	IC	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid (1-43), clone 9C4	0.2 mL	H, R	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody

• Amyloid β
  Amyloid β는 플라크를 형성하여 축적됨으로서 알츠하이머 병을 유발하고, Amyloid precursor protein의 대사산물로 39에서 43개의 아미노산으로 이루어진 다양한 길이로 존재합니다.
  

  WB: Amyloid β polypeptides were probed with Anti-Amyloid β (Aβ)x-43, clone 9C4. Lane 1: amyloid β1-40; Lane 2: amyloid β1-42 Lane 3: amyloid β1-43. Data courtesy of Joseph Buxbaum, Mt. Sinai School of Medicine.
  

  WB: Amyloid β polypeptides were probed with Anti-Amyloid β (Aβ)x-40, clone 11A5-B10 (1:1,000 dilution). Lane 1: amyloid b1-40; Lane 2: amyloid b1-42; Lane 3: amyloid b1-43. Data courtesy of Joseph Buxbaum, Mt. Sinai School of Medicine.

  Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  Amyloid β (Aβ)x-43, clone 9C4	100 μL	H, M	WB, IH	Mouse	Ascites	Monoclonal Antibody
  Amyloid β (Aβ)x-40, clone 11A5-B10	100 μL	H, M	WB, IH	Mouse	Ascites	Monoclonal Antibody
  Amyloid β (Aβ)x-42, clone 12F4	100 μL	H, M	WB, IH	Mouse	Ascites	Monoclonal Antibody
  β-Amyloid (1-8), clone 1E11	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-8), clone 2H4	0.2 mL	H	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid, clone 20.1	0.2 mL	H	IC	Mouse	Purified	Monoclonal Antibody
  Amyloid-β (Aβ), clone NAB 228	0.2 mL	H	WB, IH, ELISA, IP	Mouse	Ascites	Monoclonal Antibody
  β-Amyloid (1-16), clone 6E10	0.2 mL	H	IC	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-16)	0.2 mL	H	WB, IC, ELISA	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid, Rodent Specific	50 ug	Rodent	WB, IC, ELISA	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid (17-24), clone 4G8	0.2 mL	H, R	IC	Mouse	Purified	Monoclonal Antibody
  β-Amyloid (1-40), clone 11A50-B10	0.2 mL	H, R	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody
  β-Amyloid 40	50 ug	H, R	IC	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid (1-42), clone 12F4	0.2 mL	H, R	0.2 mL	Mouse	Purified	Monoclonal Antibody
  β-Amyloid 42	0.2 mL	H, R	IC	Rabbit	Purified	Polyclonal Antibody
  β-Amyloid (1-43), clone 9C4	0.2 mL	H, R	WB, IC, ELISA	Mouse	Purified	Monoclonal Antibody

• TH (Tyrosine Hydroxylase)
  Tyrosine hydroxylase는 아드레날린 작용의 생리적 기능에 있어 중요한 역할을 합니다.
  도파민에 반응하고 노르아드레날린에 의해 활성화 되는 neuron에 대한 유용한 마커로, westhern blot에서 약 59-63 kDa 의 사이즈를 나타냅니다.
  

  Mouse anti-Tyrosine Hydroxylase (Catalog Number MAB318) staining of embryonic rat mesencephalic dopaminergic neurons.

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  MAB5278	Tryptophan Hydroxylase/ Tyrosine Hydroxylase/ Phenylalanine Hydroxylase, clone PH8-1	500 μg	H	IP, WB, IH	Mouse	Purified	Monoclonal Antibody
  IHCR1005-6	Tyrosine Hydroxylase, prediluted, clone LNC1	6 mL	Ch, H, M, Mk, R, Fg, Lz, Vo, Zebrafish	IH(P)	Mouse	Purified	Polyclonal Antibody
  MAB318	Tyrosine Hydroxylase, clone LNC1	100 μL	Ch, H, M, Mk, R, Fg, Lz, Vo, Zebrafish	IP, WB, IH, IH(P)	Mouse	Ascites	Monoclonal Antibody

• O4
  O4는 cell body와 중추신경계에 존재하는 oligodendrocyte Ⅰ과 Ⅱ타입의 마커로, myelination, demyelination과 remyelination연구와 regeneration 실험 등에 이용될 수 있습니다.

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  MAB345	O4, clone 81 (also referred to in the literature as mAB O4)	50 μg	Ch, H, M, R	IC, IH , not IP, not WB	Mouse	Purified	Monoclonal Antibody

• GFAP (Glial Fibrillary Acidic Protein)
  Glial Fibrillary Acidic Protein은 class-III intermediate filament로, 성상세포에서 중간섬유의 주 구성분을 이루며, 중추신경계가 발생하는 동안 다른 glial세포로부터 분화된 성상세포를 구별하는 cell specific marker로서의 역할을 합니다.
  

  
  Mouse anti-GFAP (Catalog Number MAB360). Immunolocalization of GFAP (red) and MAP2 (blue) in rat hippocampus. Photo courtesy of Karl A. Kasischke & Patricia J. Fisher, Cornell University, Ithaca, NY.

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  AB9598	Glial fibrillary acidic protein δ	100 μL	H	WB, IH(P)	Rabbit	Serum	Polyclonal Antibody
  AB5804	Glial Fibrillary Acidic Protein	50 μL	B, Ca, H, R	IC, IH	Rabbit	Serum	Polyclonal Antibody
  MAB360	Glial Fibrillary Acidic Protein, clone GA5	100 μL	B, Ch, H, M, Po, R, Rb	WB, IC, IH, IH(P)	Mouse	Ascites	Monoclonal Antibody

• nTyr (Nitrotyrosine)
  Nitrotyrosine은 NO의 생산 뿐만 아니라, 세포손상과 염증의 지시기로 동정되어 있습니다.
  Nitrotyrosine의 농도 측정으로 NO에 의해 세포가 손상된 정도를 알 수 있으며, nitrotyrosin은 류마티스 관절염과 같은 염증 상태에서 발견됩니다.
  

  Immunoblot Analysis

  Representative blot from a previous lot. Nitrotyrosine immunoblotting controls were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-Nitrotyrosine (2μg/ml). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates nitrotyrosine molecular weight standards.

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  16-207	Nitrotyrosine, clone 1A6, HRP conjugate	50 μL	All	ELISA, WB	Mouse	HRP	Monoclonal Antibody
  06-284	Nitrotyrosine	100 μg	All	IP, WB, IC, IH	Rabbit	Purified	Polyclonal Antibody
  05-233	Nitrotyrosine, clone 1A6	100 μg	Vrt	IP, WB, IC, IH	Mouse	Purified	Monoclonal Antibody

• ChAT (Choline Acetyltransferase)
  Choline Acetyltransferase는 뉴런의 body에서 합성되어 축삭운반을 통해 nerve terminal로 이동되는 효소입니다.
  ChAT의 역할은 Acetyl-Co A를 choline에 연결하여 신경전달물질인 acetylcholine을 만드는 것입니다.
  

  
  Coronal section of rat neocortex stained with catalog number AB144P showing the choline acetyltransferase positive cholinergic nerve fibers and terminals. Reference: D. Anandh, K Shobha and Dr. Bindu M Kutty, Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore, India.

  Cat. No.	Product	Size	Species Reactivity	Key Applications	Host	Format	Antibody Type
  AB144P	Choline Acetyltransferase	500 μL	Av, Ch, Gp, H, M, Mk, R, Opposum	EM, WB, IC, IH	Goat	Affinity Purified	Polyclonal Antibody
  MAB305	Choline Acetyltransferase, clone 1E6	100 μL	H, Mk, R	IH	Mouse	Ascites	Monoclonal Antibody
  MAB5270	Choline Acetyltransferase, clone 1.B3.9B3	50 μg	H, Po, R	ELISA, WB, IH, IH(P)	Mouse	Purified	Monoclonal Antibody