Chloride(Cl^-) Channel Products

Chloride channel은 cell volume과 pH조절, 세포막전위 안정화, 신호전달, 세포내 물질의 산화등에 관여합니다. CLC chloride channel에는 cAMP-activated channel과 voltage-gated channel이 있는데 cAMP-activated channel에 결함이 생기면 fluid 분비이상으로 cystic fibrosis (CF)가 유발됩니다. Voltage-gated channel중 하나인 CLC-2는 GABA-A 수용체의 활성과 신경흥분조절에 영향을 줍니다.

Rat lungs sections were incubated with Anti-CFTR primary antibody (# ACL-006) (left panel).
Strong staining of bronchial epithelial cells (red) and lighter staining of alveolar cells (red-brown) is apparent.
There is also positive staining of macrophages while smooth muscle and endothelium are negative. Counter stain of cell nuclei appears blue. A negative control is shown in the right panel.

Immunohistochemical staining of CLC5 in rat kidney using Anti-CLC5 antibody (#ACL-003).
CLC5 was visualized with immuno-peroxidase methods and final brown-black diaminobenzidine color product (arrows in A). The counterstain is cresyl violet.
When the antibody was pre-incubated with the immunogen, staining was blocked (B).

• Ca²⁺ Channel Blockers Econokit
• Calcium(Ca²⁺) Channel Products
• Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors
• Fluorescently Labeled Antibodies
• Intracellular Ca2+ Modulators EconoKit
• Ion Channel Antibodies
• Ion Channel Cell Line
• Potassium(K⁺) Channel Products
• Sodium(Na⁺) Channel Products