Protein Phosphatase Inhibitors Econokit

구성품

Product	Cat. No.	Size	Purity	Biological Activity
Bioallethrin	B-300	1 mg	>98%	Although bioallethrin is a type I pryrethroid, its effects on calcineurin resemble those of Type II Pyrethrins which are very weak, bioallethrin is a potent calcinerin inhibitor, with an IC50 of about 1-2 nM.
Calyculin A	C-100	10 μg	>99%	Highly specific inhibitor for PP-1 and PP-2A phosphatases in comparison to its effect in various acid,alkaline,and protein tyrosine phosphatases.CA is 20-300-fold more potent than OA in inhibiting various PP-1 phosphatases.Its concentrationdependent effects in intact cells are easier to interpret than those of OA.
Cantharidic Acid	C-250	1 mg	>99%	Like Cantharidin, Cantharidinic Acid has been a useful tool in studying the role of protein phosphatase in regulation of various physiological functions.
Cantharidin	C-170	1 mg	>98%	Potent inhibitor of protein phosphatase 2A(IC50=40nM).
Cyclosporin A	C-900	25 mg	>97%	Cyclosporin A is a cyclic peptide that serves as an immunosuppresant, hypertension inducer and antifungal agent by its ability to inhibit Calcineurin (PP-2B).
Cypermethrin	C-470	1 mg	>98%	A type II pyrethrin; potent inhibitor of calcineurin, with an IC50 of about 40 pM (the dose-response curve is complex, however).
Deltamethrin	D-500	0.5 mg	>99%	Potent pyrethroid insecticide, specific inhibitor of Calcineurin (PP-2B) with an IC50 of about 100 pM.
Endothall	E-180	5 mg	>98%	Like other Cantharidin analogs, Endothall has been employed as a useful PP-2A inhibitor. In addition, protein phosphatase inhibition by Endothall has been used in the study of cardiac contractile, electrophysiological nd biochemical aspects, and characterization of hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-trided rats.
Fenvalerate	F-420	1 mg	>99%	A type II pyrethroid; potent inhibitor of calcineurin, with an IC50 of about 2-4nM.
FK-506	F-900	1 mg	>98%	FK 506 is potent immunosuppressive compounds that inhibit T-cell activation (10 to 100 times more potent than Cyclosporin A). FK-506 inhibits the heterodimeric Ca2+ /calmodulin-dependent phosphatase Calcineurin.
Okadaic Acid (Ammonium Salt)	O-800	25 μg	>98%	Okadaic Acid is a marine toxin, polyether derivative, produced by dinoflagellates. It is a potent, ell-permeable, specific inhibitor of PP-1 and PP2A, in numerous cell types.
Okadaol	O-700	10 μg	>98%	Okadaic acid derivate with novel pharmacological profile.
Okadiac Acid (Sodium Salt)	O-900	25 μg	>98%	Okadaic Acid is a marine toxin, polyether derivative, produced by dinoflagellates. It is a potent, ell-permeable, specific inhibitor of PP-1 and PP2A, in numerous cell types.
Permethrin	P-400	0.4 mg	>99%	A type I pyrethroid; weakly active negative control for studies of calcineurin inhibition by the more active type II pyrethroids such as Deltamethrin and Fenvalerate.
Phenylarsine Oxide	-	100 mg	>99%	Putative inhibitor of tyrosine phosphatases activity. Does not affect tyrosine kinase.
Pyrophosphate (Sodium Salt)	-	500 mg	>98%	Strong inhibitor of protein phosphatases. Effect similar to sodium fluoride and Vanadate.
Sodium Fluoride	-	500 mg	>99%	Strong inhibitor of protein phosphatases (acid, alkaline, P2, 2A). Effect similar to Pyro-phosphate and Vanadate.
Vanadate (Orthovanadate)	-	100 mg	>95%	A general potent protein phosphatases inhibitor.

• Anti-Phosphoserine, clone 4A4
• Anti-Phosphotyrosine, 4G10® Platinum
• Phosphatase Proteins
• Phospho-Specific Antibodies
• Protease Inhibitor
• Protease and Phosphatase Inhibitor Cocktails
• Protein Phosphorylation Reagents