Immunology Research Inhibitors

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Antivirals

2513	Acyclovir	Inhibits viral DNA polymerase; antiherpetic agent
1777	Arctigenin	Potent MKK1 inhibitor. Also inhibits IκBα phosphorylation
2457	Arcyriaflavin A	Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)
3666	Tenofovir	Reverse transcriptase inhibitor

Chemokine Receptors

3299	AMD 3100 octahydrochloride	Highly selective CXCR4 antagonist
3444	Anti-DARC	Antibody recognizing DARC
3129	BMS CCR2 22	High affinity, potent CCR2 antagonist
2769	BX 513 hydrochloride	Selective CCR1 antagonist
3581	C 021 dihydrochloride	Potent CCR4 antagonist
2423	DAPTA	Chemokine receptor 5 (CCR5) antagonist
2595	J 113863	Potent CCR1 chemokine receptor antagonist
2089	RS 102895 hydrochloride	CCR2b chemokine receptor antagonist
2517	RS 504393	Highly selective CCR2 chemokine receptor antagonist
2725	SB 225002	Potent and selective CXCR2 antagonist
2724	SB 265610	Potent CXCR2 antagonist
3650	SB 328437	Potent and selective CCR3 antagonist
3664	Teijin compound 1	Potent CCR2b antagonist
2757	UCB 35625	Potent CCR1 and CCR3 antagonist
2565	ZK 756326	Selective, non-peptide CCR8 agonist

Complement

2585	Compstatin	C3-binding protein, inhibits complement activation
3796	Compstatin control peptide	Control peptide for Compstatin (Cat. No. 2585)

COX

2796	(S)-(+)-Ibuprofen	Cyclooxygenase inhibitor (COX-1 > COX-2)
1706	Acetaminophen	Cyclooxygenase inhibitor; may be selective for COX-3
3461	Anti-COX-1	Antibody recognizing COX-1
3462	Anti-COX-2	Antibody recognizing COX-2
3786	Celecoxib	Selective cyclooxygenase-2 (COX-2) inhibitor
1430	DuP 697	Cyclooxygenase-2 (COX-2) inhibitor
3871	Etodolac	Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID
2776	FK 3311	Cyclooxygenase-2 (COX-2) inhibitor
1769	Flurbiprofen	Cyclooxygenase inhibitor
1507	FR 122047 hydrochloride	Cyclooxygenase (COX-1) inhibitor
1708	Indomethacin	Cyclooxygenase inhibitor (COX-1 > COX-2)
2655	Naproxen sodium	Cyclooxygenase inhibitor
2470	Nimesulide	Cyclooxygenase-2 (COX-2) inhibitor
0942	NS 398	Cyclooxygenase (COX-2) inhibitor
0960	Piroxicam	Cyclooxygenase (COX-1) inhibitor
1418	Resveratrol	Cyclooxygenase inhibitor
1550	SC 560	Cyclooxygenase (COX-1) inhibitor
2895	SC 58125	Selective cyclooxygenase-2 (COX-2) inhibitor
1707	Sulindac	Cyclooxygenase inhibitor (following metabolism to sulindac sulfide)
2580	Tenidap	NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3

Cytokines and Cytokine Receptors

1793	AF 12198	Potent, selective human type I IL-1 receptor antagonist
0414	AG 490	EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
2446	AS 101	Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
1743	Bay 11-7085	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
1744	Bay 11-7821	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
2743	Caffeic acid phenethyl ester	Specific inhibitor of NF-κB activation
3203	Celastrol	Antioxidant and anti-inflammatory
2471	ER 27319 maleate	Selective Syk kinase inhibitor
1798	Gabexate mesylate	Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
3270	GIT 27	Immunomodulator; reduces production of pro-inflammatory cytokines
2637	Gliotoxin	Immunosuppressant; inhibits NF-κB and cytokine production
2861	HU 211*	NMDA receptor antagonist. Also NF-κB inhibitor
2539	IKK 16	Selective inhibitor of IKK
2611	IMD 0354	Inhibitor of IKK-2
2265	Lyn peptide inhibitor	Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
1554	Piceatannol	Inhibits TNF-induced NF-κB activation
1093	Pirfenidone	Antifibrotic agent; regulates cytokine levels in vivo
1794	Ro 26-4550 trifluoroacetate	Competitive inhibitor of IL-2/ IL-2Rα receptor interaction
3318	SC 514	IKK-2 inhibitor; attenuates NF-κB-induced gene expression
2008	SKF 86002 dihydrochloride	p38 MAP kinase inhibitor; anti-inflammatory agent
2798	Stattic	Selective STAT3 inhibitor
3543	Suplatast tosylate	Th2 cytokine synthesis inhibitor; antiasthmatic
0652	Thalidomide	TNF-α synthesis inhibitor
2559	TPCA-1	Potent, selective inhibitor of IKK-2
3253	Triptolide	Inhibits TNF-α-induced NF-κB activation
2816	Withaferin A	Inhibits NF-κB activation
1675	YM 90709	Interleukin-5 receptor antagonist

Glococorticoid Receptors

2671	Budesonide	Synthetic glucocorticoid; anti-inflammatory and chemopreventive
3685	Corticosterone	Endogenous glucocorticoid
1126	Dexamethasone	Anti-inflammatory glucocorticoid
2007	Fluticasone propionate	Selective high affinity glucocorticoid agonist
3572	GSK 650394	Serum- and glucocorticoid-regulated kinase (SGK) inhibitor
1479	Mifepristone	Progesterone and glucocorticoid antagonist
3570	Z-Guggulsterone	Broad spectrum steroid receptor ligand. More active isomer of Cat. No 2013

Histamine Receptors

0569	(R)-(-)-α-Methylhistamine dihydrobromide	Potent, standard H3 agonist
1425	(S)-(+)-Dimethindene maleate	M2-selective antagonist
0572	(S)-(+)-α-Methylhistamine dihydrobromide	H3 agonist, less active enantiomer
2478	2-Pyridylethylamine dihydrochloride	H1 receptor agonist
2342	4-Methylhistamine dihydrochloride	Selective, high affinity H4 agonist
3753	A 943931 dihydrochloride	Potent and selective H4 antagonist
3640	A 987306	Potent and selective H4 receptor antagonist
0721	Aminopotentidine	H2 antagonist
0668	Amthamine dihydrobromide	Highly selective standard H2 agonist
0791	Antazoline hydrochloride	Imidazoline ligand
3489	Astemizole	Orally active, potent H1 antagonist. Also hERG K+ channel blocker.
1857	Burimamide oxalate	Mixed H2/H3 antagonist
2211	Carcinine ditrifluoroacetate	Highly selective H3 antagonist
2577	Cetirizine dihydrochloride	Selective H1 antagonist
0902	Cimetidine	H2 antagonist, I1 agonist
1453	Clemastine fumarate	H1 antagonist
0752	Clobenpropit dihydrobromide	Highly potent H3 antagonist and H4 partial agonist
2409	Conessine	Potent and selective H3 receptor antagonist
0506	Dimaprit dihydrochloride	Standard H2 selective agonist
3072	Diphenhydramine hydrochloride	H1 receptor antagonist
0508	Doxepin hydrochloride	Highly potent H1 antagonist. Also binds to H4 receptor
0743	DPPE fumarate	Inhibitor of histamine binding at the intracellular binding site
2429	Fexofenadine hydrochloride	H1 receptor antagonist; non-sedating antiallergic agent
3545	Histamine dihydrochloride	Endogenous histamine receptor agonist
0646	HTMT dimaleate	H1 / H2 agonist
0833	ICI 162,846	Potent H2 antagonist, active in vivo
0729	Imetit dihydrobromide	Standard H3 and H4 agonist (H3 > H4)
0932	Immepip dihydrobromide	Standard H3 agonist. Also H4 agonist
2315	Immethridine dihydrobromide	Potent H3 agonist, highly selective over H4
1858	Impentamine dihydrobromide	Selective H3 antagonist
0779	Iodophenpropit dihydrobromide	Potent, selective H3 antagonist
2441	JNJ 10191584 maleate	Selective H4 receptor antagonist; orally active
0784	Ketotifen fumarate	H1 antagonist
1944	Loratidine	Peripheral H1 antagonist; antiallergic agent
0660	Mepyramine maleate	Selective H1 inverse agonist
2947	Methimepip dihydrobromide	Extremely selective H3 agonist
2018	Mirtazapine	Potent 5-HT2 antagonist. Also 5-HT3, H1 and α2-antagonist. Antidepressant
0573	Nα-Methylhistamine dihydrochloride	Non-selective H3 agonist
2477	Proxyfan oxalate	High affinity H3 ligand
1967	Ranitidine hydrochloride	Selective H2 antagonist
2034	ROS 234 dioxalate	Potent H3 antagonist
0512	SKF 91488 dihydrochloride	Histamine N-methyltransferase inhibitor
0644	Thioperamide	H3 antagonist and H4 inverse agonist
0826	Tiotidine	Potent, selective H2 antagonist
0662	trans-Triprolidine hydrochloride	Standard H1 antagonist, highly potent
2493	VUF 5681 dihydrobromide	Potent H3 receptor silent antagonist
2494	VUF 8430 dihydrobromide	Potent, high affinity H4 agonist
1070	Zolantidine dimaleate	Potent, centrally active H2 antagonist

iNOS Siganling

0776	(S)-Methylisothiourea sulfate	Highly selective iNOS inhibitor
1415	1400W dihydrochloride	Potent, highly selective iNOS inhibitor
0951	2-Iminopiperidine hydrochloride	Selective iNOS inhibitor
0787	Aminoguanidine hydrochloride	Irreversible iNOS inhibitor
0871	AMT hydrochloride	Potent, selective iNOS inhibitor
2866	BYK 191023 dihydrochloride	Potent and selective inhibitor of iNOS
0873	EIT hydrobromide	Selective iNOS inhibitor, acts arginine binding site
1139	L-NIL hydrochloride	Selective iNOS inhibitor
0897	S-Isopropylisothiourea hydrobromide	iNOS inhibitor, acts arginine binding site

JAK Siganling

2291	1,2,3,4,5,6-Hexabromocyclohexane	Inhibits JAK2 autophosphorylation
0414	AG 490	EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
1571	Cucurbitacin I	Selective inhibitor of STAT3/JAK2 signaling
3395	Lestaurtinib	JAK2, FLT3 and TrkA inhibitor
3115	WHI-P 154	JAK3 kinase inhibitor. Also inhibits EGFR
1367	ZM 39923 hydrochloride	Potent, selective JAK3 inhibitor
1366	ZM 449829	Potent, selective JAK3 inhibitor

JNK Signaling

2651	AEG 3482	Inhibitor of JNK signaling
1290	Anisomycin	Protein synthesis inhibitor
3314	BI 78D3	Selective, competitive JNK inhibitor
1989	c-JUN peptide	Peptide inhibitor of JNK/c-Jun interaction
1565	JIP-1 (153-163)	JNK-selective inhibitor peptide
1496	SP 600125	Novel and selective JNK inhibitor
3607	SU 3327	Selective JNK inhibitor
2827	TCS JNK 5a	Selective inhibitor of JNK2 and JNK3

p38 Signaling

1290	Anisomycin	Protein synthesis inhibitor
3465	Anti-ERK2	Antibody recognizing ERK2
3314	BI 78D3	Selective, competitive JNK inhibitor
2344	CGH 2466 dihydrochloride	A1, A2B and A3 antagonist and inhibitor of p38 MAPK and PDE4
2186	CMPD-1	Non-ATP-competitive p38α inhibitor
2908	EO 1428	Selective inhibitor of p38α and p38β2
2657	JX 401	Potent, reversible p38α inhibitor
2244	p38 MAPK Inhibitor TocrisetTM	Selection of 3 p38 MAPK inhibitors (Cat. Nos. 1264, 1202 and 1962)
2999	RWJ 67657	Potent, selective p38α and p38β inhibitor
1264	SB 202190	Potent, selective inhibitor of p38 MAPK
1202	SB 203580	Selective inhibitor of p38 MAPK
1402	SB 203580 hydrochloride	Selective inhibitor of p38 MAPK; water-soluble
1962	SB 239063	Potent, selective p38 MAP kinase inhibitor; orally active
2938	SD 169	Selective, orally active p38α inhibitor
2008	SKF 86002 dihydrochloride	p38 MAP kinase inhibitor; anti-inflammatory agent

Raf Signaling

1850	Exo1	Inhibits Golgi-ER traffic; blocks exocytosis
3631	FK 506	Potent calcineurin inhibitor; immunosuppressant
1381	GW 5074	Potent, selective c-Raf1 kinase inhibitor
3143	KM 11060	Corrects F508del-CFTR trafficking
3185	L-779,450	Potent Raf kinase inhibitor
1899	Sarafotoxin S6a	Endothelin receptor agonist
1174	Sarafotoxin S6b	Endothelin receptor agonist, non-selective
1175	Sarafotoxin S6c	Selective ETB agonist
1321	ZM 336372	Potent, selective c-Raf inhibitor

Src Signaling

3063	1-Naphthyl PP1	Src family kinase inhibitor; also inhibits c-Abl
1935	Caffeic acid-pYEEIE	Phosphopeptide ligand for src SH2 domain
1629	Herbimycin A	Src family kinase inhibitor. Also Hsp90 inhibitor
1331	Lavendustin A	EGFR, p60c-src inhibitor
2265	Lyn peptide inhibitor	Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
2877	MNS	Selective inhibitor of Src and Syk
1930	N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide	Phosphopeptide ligand for src SH2 domain
1927	N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu	Phosphopeptide ligand for src SH2 domain
1397	PP 1	Potent, selective Src inhibitor
1407	PP 2	Potent, selective Src inhibitor
2794	PP 3	Negative control for PP 2 (Cat. No. 1407)
1923	pp60 c-src (521-533) (phosphorylated)	Inhibits tyrosine kinase activity of pp60c-src and pp60v-src
1155	RR-src	Tyrosine kinase substrate peptide
3642	Src I1	Dual site Src kinase inhibitor

Syk Signaling

3446	Anti-14.3.3σ	DLHTLSEDSYKDST
2471	ER 27319 maleate	Selective Syk kinase inhibitor
2877	MNS	Selective inhibitor of Src and Syk
1554	Piceatannol	Inhibits TNF-induced NF-κB activation

Integrin Receptors

3202	Echistatin, α1 isoform	αVβ3 and glycoprotein IIb/IIIa (αIIbβ3) inhibitor
1263	GR 144053 trihydrochloride	Glycoprotein IIb/IIIa (αIIbβ3) receptor antagonist. Antithrombotic
3498	RGDS peptide	Integrin binding sequence; inhibits integrin receptor function

Leukotriene Receptors

1796	5-Oxo-ETE	Oxoeicosanoid receptor agonist
2756	Arachidonic acid (in TocrisolveTM 100)	Endogenous free fatty acid (in water-soluble emulsion)
3138	BAY-u 9773	Dual CysLT1 and CysLT2 antagonist
2025	Cinalukast	Potent, selective CysLT1 (LTD4) antagonist; orally active
2276	FPL 55712	Leukotriene receptor antagonist
2307	Leukotriene B4	BLT1/BLT2 receptor agonist and potent chemotactic factor
2208	LY 255283	Selective, competitive BLT2 receptor antagonist
2338	MK 571	Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor
3026	ONO 1078	Selective CysLT1 antagonist
1804	SR 2640 hydrochloride	Potent, selective LTD4 /LTE4 receptor antagonist

LOX

0645	2-TEDC	5-, 12-, 15-Lipoxygenase inhibitor
1761	Baicalein	5- and 12-Lipoxygenase inhibitor
1304	BW-B 70C	5-Lipoxygenase inhibitor
1311	MK 886	Inhibitor of 5-lipoxygenase-activating protein (FLAP)
2850	PD 146176	Selective 15-lipoxygenase inhibitor
2204	STEARDA	Endogenous inhibitor of 5-lipoxygenase
3308	Zileuton	Orally active 5-LOX inhibitor

PAF Receptors

3022	Edelfosine	Selective PI-PLC inhibitor, also PAF receptor agonist
1657	Ginkgolide B	PAF receptor antagonist
2940	PAF (C16)	Endogenous platelet-activating factor (PAF)
0571	PCA 4248	PAF receptor antagonist
2339	WEB 2086	Potent PAF receptor antagonist

Prostanoid Receptors

2295	(±)-Cloprostenol sodium salt	Water-soluble PGF2α analog and potent FP receptor agonist
3025	AA 2414	Thromboxane A2 (TP) receptor antagonist
0671	AH 6809	EP1 and EP2 receptor antagonist
1620	Alprostadil	Prostaglandin. Vasodilator and antiplatelet agent in vivo
2756	Arachidonic acid (in TocrisolveTM 100)	Endogenous free fatty acid (in water-soluble emulsion)
2732	BAY-u 3405	Dual TP/DP2 (CRTH2) receptor antagonist
1442	BMY 45778	Non-prostanoid prostacyclin IP receptor partial agonist
2989	Epoprostenol	Endogenous IP receptor agonist
0836	ICI 185,282	Potent thromboxane receptor antagonist
2038	Iloprost	Prostacyclin (PGI2) analog
2514	L-161,982	Selective EP4 receptor antagonist
3342	L-798,106	Potent and highly selective EP3 antagonist
2297	Misoprostol	Cytoprotective PGE1 analog
2296	Prostaglandin E2	Major endogenous prostanoid
1206	SC 19220	Selective EP1 receptor antagonist
3758	SC 51089	Selective EP1 receptor antagonist

TGF-beta Receptors

2939	A 83-01	Selective inhibitor of TGF-βRI, ALK4 and ALK7
2902	D 4476	Selective CK1 inhibitor. Also inhibits TGF-βRI
2718	LY 364947	Selective inhibitor of TGF-βRI
1614	SB 431542	Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
3211	SB 525334	Selective inhibitor of TGF-βRI
3269	SD 208	Potent ATP-competitive TGF-βRI inhibitor

Toll-like Receptors

3270	GIT 27	Immunomodulator; reduces production of pro-inflammatory cytokines
3700	Imiquimod	Toll-like receptor 7 (TLR7) agonist
2719	RWJ 21757	Toll-like receptor 7 (TLR7) agonist