Protease Inhibitor

종류

Cat. No.	Name	Product	Biological Activity
251700	1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride	1,5-DNS-GGACK, 2HCl	Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.
178196	α1-Antichymotrypsin, Human Plasma	α1-Achy, α1-1X, α1-1X-Glycoprotein	An acute phase plasma protein that functions as a specific inhibitor of chymotrypsin-like serine proteases.
178251	α1-Antitrypsin, Human Plasma	α1-AT, α1-Proteinase Inhibitor, 3.5S α1-Glycoprotein	A serine protease inhibitor that also acts as a major physiological regulator of elastase.
126850	α1-PDX, Human, Recombinant, E. coli	α1-Antitrypsin Portland	Extracellular application of α1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.
178221	α2-Antiplasmin, Human Plasma	α2-Protease Inhibitor, Primary Plasmin Inhibitor	Efficiently inhibits the plasminogen activator-induced lysis of fibrin clots. Forms a covalent complex with plasmin and inactivates it.
369334	2-Guanidinoethylmercaptosuccinic Acid	GEMSA	Potent inhibitor of a carboxypeptidase B-like processing enzyme referred to as enkephalin convertase (Ki=8.8 nM). Ideal for use in affinity chromatography of the enzyme.
441251	α2-Macroglobulin, Human Plasma	α2M, α2MG
287815	3,4-Dichloroisocoumarin	3,4-Dichloroisocoumarin	A potent irreversible inhibitor of serine proteases. Reacts with serine proteases to release acyl chloride moiety that can acylate another active site residue. Has no action on thiol proteases and metalloproteases.
110175	Acetyl-Pepstatin	Ac-Val-Val-(3S,4S)-Sta-Ala-(3S,4S)-Sta-OH	An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase.
101500	AEBSF, Hydrochloride	4-(2-Aminoethyl)benzenesulfonylfluoride, HCl	Water-soluble, non-toxic alternative to PMSF. Irreversible inhibitor of serine proteases. Reacts covalently with a component of the active site. Inhibits chymotrypsin, kallikrein, plasmin, trypsin, and related thrombolytic enzymes.
208721	ALLM	Calpain Inhibitor II	Inhibitor of calpain I (Ki=120 nM), calpain II (Ki=230 nM), cathepsin B (Ki=100 nM), and cathepsin L (Ki=600 pM).
208719	ALLN	LLNL, MG 101, Calpain Inhibitor I	Cell-permeable inhibitor of calpain I (Ki=190 nM), calpain II (Ki=220 nM), cathepsin B (Ki=150 nM), and cathepsin L (Ki=500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki=6 uM).
129875	Amastatin, Streptomyces sp.	(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp-OH	Binds to cell surfaces and reversibly inhibits aminopeptidases. A slow binding, competitive inhibitor of aminopeptidase M and leucine aminopeptidase. Has no significant effect on aminopeptidase B.
1381	ε-Amino-n-caproic Acid	Phosphocreatine, 2Na	Lysine analog that inhibits carboxypeptidase B. Promotes rapid dissociation of plasmin by inhibiting activation of plasminogen by streptokinase.
164606	Aminopeptidase N/CD13 Inhibitor	4-tert-butylphenyl hydrogen 1-aminopropylphosphonate	An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC50=1.1 uM).
178223	Antipain, Dihydrochloride	Antipain, Dihydrochloride	Peptidyl arginine aldehyde protease inhibitor produced by H2O actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50=300 μM).
178220	Antipain, Hydrochloride	Antipain, Hydrochloride	A reversible inhibitor of cysteine and serine proteases.
169756	Antithrombin III, Human Plasma	ATIII, Heparin cofactor, Factor Xa inhibitor	Complexes with serine proteases of blood coagulation system including thrombin, plasmin, kallikrein, and factors IXa, Xa, Xla, and concentrations. XIIa. Potency is strongly enhanced in the presence of heparin.
616370	Aprotinin, Bovine Lung, Crystalline	Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor	A competitive and reversible inhibitor of esterases and proteases.
616399	Aprotinin, Bovine Lung, Solution	Kallikrein Inactivator	A competitive and reversible inhibitor of proteolytic and esterolytic activity. A serine protease inhibitor. In cell cultures, extends the life of cells and prevents proteolytic damage to intact cells.
616371	Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free	Basic Pancreatic Trypsin Inhibitor, Kallikrein-Trypsin Inactivator, Pancreatic Trypsin Inhibitor, Antikrein, Trypsin-Kallikrein Inhibitor	Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor.
199001	Benzamidine, Hydrochloride	Benzamidine, Hydrochloride	Inhibitor of trypsin and trypsin-like enzymes. Inhibits Factor VII autoactivation.
200484	Bestatin	[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu	Binds to cell surfaces and inhibits cell surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase.
200485	Bestatin Methyl Ester	(-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester	A cell-permeable derivative of Bestatin that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.
205530	CA-074	Cathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline	An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50=2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death.
205531	CA-074 Me	Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester	A cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
208900	Calpastatin, Human, Recombinant, Domain I	Calpastatin	A potent inhibitor of calpain, a Ca2+-dependent cysteine protease. Has greater inhibitory action than calpain inhibitors I and II. Inhibitory sequence has 18 amino acid residues.
03-34-0051	Calpeptin	Benzyloxycarbonylleucyl-norleucinal	A cell-permeable calpain inhibitor. Inactivates calpain I (ID50=52 nM), calpain II (ID50=34 nM), and papain (ID50=138 nM).
342000	Caspase Inhibitor, Negative Control	Z-FA-FMK, Cathepsin B, Inhibitor I	A cathepsin B inhibitor. Suitable as a negative control for caspase-1.
219385	Cathepsin B Inhibitor II	Ac-LVK-CHO	A more active lysinal analog of leupeptin. Inhibits cathepsin B at nanomolar levels (IC50=4 nM).
219372	Cathepsin G Inhibitor I	Cathepsin G Inhibitor I	A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. Weakly inhibits chymotrypsin (Ki=1.5 uM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase.
219415	Cathepsin Inhibitor I	CATI -1, Z-FG-NHO-Bz	Cell-permeable cysteine protease inhibitor.
219417	Cathepsin Inhibitor II	Z-FG-NHO-BzME	Cysteine protease inhibitor. Selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain.
219419	Cathepsin Inhibitor III	Z-FG-NHO-BzOME	Cysteine protease inhibitor. Selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain.
219377	Cathepsin K Inhibitor I	1,3-Bis(CBZ-Leu-NH)-2-propanone, 1,3-Bis(N-carbobenzoyloxy-L-leucyl)amino Acetone	A cell-permeable, symmetrical bis(acylamino)ketone that acts as a potent, selective, and reversible inhibitor of cathepsin K.
219379	Cathepsin K Inhibitor II	Z-L-NHNHCONHNH-LF-Boc, Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl leucyl)carbohydrazide	A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K.
219381	Cathepsin K Inhibitor III	1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH2, Inhibitor I	A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K.
219502	Cathepsin L Inhibitor, CAA0225	Cathepsin L Inhibitor, CAA0225	An epoxysuccinyl peptide highly selective for rat liver cathepsin L, while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro.
219421	Cathepsin L Inhibitor I	Z-FF-FMK	A potent, cell-permeable, and irreversible inhibitor of Cathepsin L.
219426	Cathepsin L Inhibitor II	Z-FY-CHO	A potent and selective inhibitor of cathepsin L.
219427	Cathepsin L Inhibitor III	Z-FY(t-Bu)-DMK	An irreversible inhibitor of Cathepsin L. About 10,000-fold more effective against cathepsin L than cathepsin S.
219433	Cathepsin L Inhibitor IV	1-Naphthalenesulfonyl-IW-CHO	A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50=1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice.
219433	Cathepsin L Inhibitor IV	1-Naphthalenesulfonyl-IW-CHO	A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50=1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice.
219393	Cathepsin S Inhibitor	Z-FL-COCHO	A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki=185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki=76 nM).
230790	Chymostatin	[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-α-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A = Leu], B = Val, C = Ile]-phenylalaninal	Contains chymostatin "A" as a major form. Protease inhibitor produced by actinomycetes. Specifically inhibits chymotrypsin, papain, and most cysteine proteases.
240896	Cystatin C, Human Urine	Post γ-globulin	A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane.
317621	Dipeptidylpeptidase II Inhibitor	DPP II Inhibitor, L-2,4-Diaminobutyrylpiperidinamide	An aminoacylpiperidine compound that acts as a potent and highly specific inhibitor of dipeptidylpeptidase II (IC50=130 nM).
416200	Dipeptidylpeptidase IV Inhibitor I	Diprotin A	A dipeptidylpeptidase IV (DPP IV) inhibitor that inhibits both endo- and exopeptidase activities of DPPIV.
317638	Dipeptidylpeptidase IV Inhibitor II	DPP IV	Acts as a potent reversible inhibitor of human placenta dipeptidylpeptidase II (Ki = 3.8 uM) and porcine kidney dipeptidylpeptidase IV (Ki = 1 uM). Combines the efficacy of aminoacyl pyrrolidides and the potential transacylating capability of diacylhydroxylamines.
317641	Dipeptidylpeptidase IV Inhibitor III	1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl	An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 uM.
317642	Dipeptidylpeptidase IV Inhibitor IV, K579	(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile	A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor. Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
445825	DL-2-Mercaptomethyl-3-guanidinoethylthiopropanoic Acid	Plummer’s Inhibitor	Potent reversible inhibitor of human plasma carboxypeptidase N (Ki=2 nM). Inhibits hydrolysis of bradykinin.
627624	D-Val-Phe-Lys Chloromethyl Ketone, Dihydrochloride	Plasmin Inhibitor, 2HCl	Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50=100 pM for human plasmin) over urokinase.
324890	E-64 Protease Inhibitor	E-64 Protease Inhibitor	Irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors.
330200	Ecotin, E. coli	Ecotin	potent, broad range inhibitor of serine proteases. Exhibits picomolar binding constant for the inhibition of chymotrypsin, elastase, Factor Xa, Factor XIIa, kallikrein, and trypsin. Also acts as an effective inhibitor of collagenase.
34103	EDTA, Tetrasodium Tetrahydrate Salt	Ethylenediaminetetraacetic Acid, 4Na, 4H2O	Organic chelating agent used in ion exchange, metal chelation, antioxidation procedures, spectrophotometric titration, and other chemical procedures.
324692	Elastase Inhibitor I	PPE Inhibitor, Boc-AAA-NHO-Bz	Serine protease inhibitor. Inhibits porcine pancreatic elastase (PPE; ki=128 M-1 sec-1) and thermitase (ki=1.14 x 103 M-1 sec-1).
324744	Elastase Inhibitor II	HNE Inhibitor, MeOSuc-AAPA-CMK, MSACK	A potent irreversible inhibitor of human neutrophil elastase (HNE). Inhibition results from cross-linking of the catalytic residues His57 and Ser195.
324745	Elastase Inhibitor III	HLE Inhibitor, MeOSuc-AAPV-CMK	A potent irreversible inhibitor of human leukocyte elastase (HLE)(Ki=10 uM). Protects against lung injury induced by instillation of elastase.
324691	Elastatinal	Elastatinal	An inhibitor of elastase-like serine protease produced by actinomycetes. Inhibits PMSF-stimulated degradation of histone H1 and HMG proteins. Also inhibits α2-macroglobulin-protease complexes.
330005	EST	Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester	A membrane permeable calpain inhibitor. Its action is similar to E-64. however, it is devoid of charged groups.
344960	FUT-175	Futhan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate	A synthetic broad-specificity serine protease inhibitor. Potently inhibits both coagulation and complement proteinases as well as Granzyme A. Also effective toward Hageman factor and Factor Xa at submicromolar concentrations.
347436	GGACK	Glu-Gly-Arg-chloromethyl Ketone	An irreversible inhibitor of urokinase (IC50 <1 uM) and Factor Xa.
377853	Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces cerevisiae	Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces cerevisiae	HV1 form devoid of sulfate residue at Tyr63. Has highly specific antithrombin properties. Inactivates thrombin by blocking substrate binding groups.
208750	InSolution™ ALLN	MG 101, Calpain Inhibitor I, LLNL	calpain 1 (Ki=190 nM), calpain II (Ki=220 nM), cathepsin B (Ki=150 nM), and cathepsin L (Ki=500 pM),neutral cysteine proteases and the proteasome (Ki=6 uM).
407710	α-Iodoacetamide	α-Iodoacetamide	An irreversible inhibitor of several cysteine proteases. Useful for alkylating cysteine and methionine residues.
407719	Iodoacetic Acid, Sodium Salt	Iodoacetic Acid, Sodium Salt	Inhibits cysteine proteases.
422686	Kininogen, High Molecular Weight, Single Chain, Human Plasma	Kininogen	Nonenzymatic cofactor of the contact activation system.
422688	Kininogen, High Molecular Weight, Two Chain, Human Plasma	Kininogen	Native, two-chain, high molecular weight Kininogen from human plasma prepared by kallikrein digestion of kininogen, which is then repurified to remove traces of kallikrein.
432077	Leuhistin	((2R,3S)-3-Amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methyl)-5-methylhexanoic Acid	Microbial product. Competitively inhibits aminopeptidase M.
108975	Leupeptin, Hemisulfate, Microbial	Ac-LLR-CHO, ½H2SO4	A reversible inhibitor of trypsin-like proteases and cysteine proteases.
108976	Leupeptin, Hemisulfate, Synthetic	Ac-LLR-CHO, 1/2H2SO4	Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.
444289	Marimastat	(2S,3R)-N4-((1S)-2,2-Dimethyl-1-((methylamino)carbonyl)propyl)-N1,2-hydroxy-3-(2-methylpropyl)butanediamide	An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor that targets both the substrate binding site and the active-site Zn2+.
616382	Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride	TLCK, Hydrochloride	An irreversible inhibitor of trypsin-like serine proteases. Inactivates trypsin, specifically and irreversibly. Does not have any significant inhibitory effect on chymotrypsin.
616387	Nα-Tosyl-Phe Chloromethyl Ketone	TPCK	An irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations.
516705	o-Phenanthroline	1,10-Phenanthroline Monohydrate	A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.
178281	p-APMSF, Hydrochloride	p-Amidinophenylmethylsulfonylfluoride, HCl	A specific irreversible inhibitor of trypsin-like serine proteases. A suitable alternative to DFP and PMSF.
516483	Pepstatin A, Penetratin	PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp43-58	A potent and selective inhibitor of thrombin. Specifically alkylates an active center histidine and thus is classified as an affinity label for thrombin.
516481	Pepstatin A, Synthetic	Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid	A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 in PC12 cell lines.
52332	Phenylmethylsulfonyl Fluoride	Benzylsulfonyl Fluoride, PMSF	Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes.
525276	Phosphoramidon, Disodium Salt	N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na	Inhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 uM).
520222	PPACK, Dihydrochloride	PPACK	A potent and selective inhibitor of thrombin. Specifically alkylates an active center histidine and thus is classified as an affinity label for thrombin.
520224	PPACK, Dihydrochloride, Biotinylated	Biotin-X-D-Phe-Pro-Arg-chloromethylketone, 2HCl	Biotin-X-analog of Cat. No. 520222. Specific probe for active serine proteases. Potent inhibitor of thrombin and tissue plasminogen activator (tPA).
520219	PPACK II, Trifluoroacetate Salt	PPACK II	Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
537011	Prolyl Endopeptidase Inhibitor II	Z-PP-CHO	A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase.
539124	Protease Arrest™ Reagent	-	An optimized concentration of various reversible and irreversible inhibitors to inhibit serine, cysteine, and calpain proteases.
539470	Proteinase K Inhibitor	MeOSuc-AAPF-CMK	A tetrapeptidyl chloromethyl ketone compound that acts as an active-site-targeting irreversible inhibitor against proteinase K.
650345	Trypsin Inhibitor, Corn	Trypsin Inhibitor	A specific inhibitor of human factor XIIa.
65035	Trypsin Inhibitor, Soybean	Trypsin Inhibitor	A reversible serine protease inhibitor. Inhibits factor Xa, trypsin, chymotrypsin, kallikrein, and plasmin.
650357	Trypsin Inhibitor, Soybean, High Activity	Trypsin Inhibitor	A reversible serine protease inhibitor. Inhibits factor Xa, trypsin, chymotrypsin, kallikrein, and plasmin.
672151	uPA Inhibitor	4-Iodo-benzo[b]thiophene-2-carboxamidine, HCl	A cell-permeable carboxamidine compound that acts as a potent substrate-competitive inhibitor of uPA, trypsin, and tryptase, with good selectivity relative to tPA, Thrombin, and Factor Xa.
421050	(Z-LL)2 Ketone	1,3-di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone	A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.

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