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 ǰȳ  Ű   Cell Biology

Cell Cycle Related Inhibitiors

Cell Cycle DNA п Ͼ Ϸ , Cell Cycle ϴµ ʿ CDK, Aurora, p53 inhibitor, activator Ұմϴ.

TOCRIS
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  • Aurora Kinases

         Aurora kinases üп ϰ , Aurora A, Aurora B ׸
         Aurora C 3 isoform  ٸ ü п մϴ.

Function Cat. No. Product Name  Activity
Inhibitor 4291 CCT 137690  Potent pan-Aurora kinase inhibitor 
Inhibitor 3988 Hesperadin hydrochloride Potent Aurora kinase B inhibitor 
Inhibitor 4821 PF 03814735  Aurora kinase A and B inhibitor 
Inhibitor 4584 SNS 314 mesylate  Potent pan-Aurora kinase inhibitor 
Inhibitor 4066 TC-A 2317 hydrochloride  Potent, selective Aurora kinase A inhibitor 
Inhibitor 5286 TC-S 7010  Potent and selective Aurora kinase A inhibitor 
Inhibitor 2458 ZM 447439 Inhibits Aurora kinase B 
Activator 3084 Anacardic acid  Aurora kinase A activator. Also inhibits histone acetyltransferase 

 

  • Cdc25 Phosphatase

          Cdc25 cdc25A, B ׸ C 3 isoform , Cell cycle ࿡ 翪 մϴ.

Function Cat. No. Product Name  Activity
Inhibitor 1867 NSC 663284  Potent, selective Cdc25 phosphatase inhibitor 
Inhibitor 1547 NSC 95397 Selective Cdc25 dual specificity phosphatase inhibitor 

 

  • Cell Cycle Inhibitors

          Cell cycle inhibitor پ Ŀ cell cycle ߰ų ߰ մϴ.

Function Cat. No. Product Name  Activity
Inhibitor 5331 CPI 203 Arrests cell cycle at G1 phase; also BET bromodomain inhibitor 
Other 4406 10058-F4  Arrests cell cycle at G0/G1 
Other 4138 ABT 751  Inhibitor of microtubule polymerization; blocks cell cycle at G2M 
Other 1761 Baicalein  Induces G1 and G2 cell cycle arrest. Also lipoxygenase inhibitor  
Other 5144 CFM 4  CARP-1 mimetic; induces G2/M cell cycle arrest 
Other 1417 Daidzein  Arrests cell cycle in G1 phase 
Other 4761 Plumbagin  Induces G2/M cell cycle arrest; anticancer
Other 5264 Temsirolimus mTOR inhibitor; arrests cell cycle at G1/S 
Other 4282 WYE 687 dihydrochloride  Potent and selective mTOR inhibitor; induces G1 cell cycle arrest 
  • Checkpoint Control Kinases

          Checkpoint control kinases Cell Cycle ݿ Ģ ֵ ϸ, ʿ
          ܰ谡 Ϸ    ܰ ϴ.

Function Cat. No. Product Name  Activity
Inhibitor 3994 AZ 3146 Potent and selective monopolar spindle 1 (Mps1) inhibitor 
Inhibitor 3544 KU 55933  Potent and selective ATM kinase inhibitor 
Inhibitor 3034 NSC 109555 ditosylate  Selective Chk2 inhibitor 
Inhibitor 3712 NU 7441  Potent and selective DNA-PK inhibitor 
Inhibitor 2694 PD 407824  Selective inhibitor of Chk1 and Wee1 
Inhibitor 4277 PF 477736 Selective Chk1 inhibitor 
Inhibitor 2560 SB 218078  Inhibitor of checkpoint kinase 1 (Chk1) 
Inhibitor 3038 TCS 2312  Potent Chk1 inhibitor 
Other 4502 DIM  Activates Chk2; induces G2/M cell cycle arrest 
Other 4763 Pyridostatin pentahydrochloride  Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest 

 

  • Cyclin-Dependent Protein Kinase

          Cdks cell-cycle control system ߿ ϳ, Cyclinܹ Ͽ cyclin D
          ü Ͽ ֱ⸦ , 12 CDK ڰ , Cdk1, -2, -3, -4, -6 5
          ڸ  ֱ⸦ ϴ ɷ ֽϴ.

Function Cat. No. Product Name  Activity
Inhibitor 3610 (R)-DRF053 dihydrochloride  Dual cdk1/cdk5 inhibitor. Also inhibits CK1 
Inhibitor 1902 [Ala92]-p16 (84-103)  Cyclin-dependent kinase inhibitor 
Inhibitor 1532 10Z-Hymenialdisine  Pan kinase inhibitor; potently inhibits Cdk1, Cdk2, Cdk3 and Cdk5 
Inhibitor 2457 Arcyriaflavin A  Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 
Inhibitor 3094 Flavopiridol hydrochloride  Cyclin-dependent kinase inhibitor 
Inhibitor 2152 NSC 625987   Cyclin-dependent kinase 4 (cdk4) inhibitor 
Inhibitor 3135 NU 2058 Cdk1 and cdk2 inhibitor 
Inhibitor 4786 PD 0332991 isethionate  Potent, selective Cdk4/6 inhibitor; brain penetrant 
Inhibitor 4181 Ro 3306  Cyclin-dependent kinase (cdk) 1 inhibitor 
Inhibitor 2907 SU 9516   Potent cdk2 inhibitor 

 

  • Mitosis

          üп ϳ κ , , , ߱, ı, 5ܰ ˴ϴ.

Function Cat. No. Product Name  Activity
Inhibitor 5399 BTB1 Selective and ATP-competitive Kif18A inhibitor 
Inhibitor 1364 Colchicine   Inhibitor of tubulin 
Inhibitor 1495 Combretastatin A4  Inhibits tubulin polymerization. Antitumor, antiangiogenic and antimetastatic 
Inhibitor 1643 D-64131  Inhibitor of tubulin polymerization. Antitumor in vivo 
Inhibitor 5261 Dimethylenastron Inhibitor of mitotic motor kinesin Eg5; antimitotic 
Inhibitor 1228 Nocodazole  Microtubule inhibitor 
Inhibitor 1232 Wortmannin  Potent inhibitor of PLK1. Also inhibitor of PI 3-kinase 
Other 3502 Epothilone B  Microtubule stabilization agent; promotes G2-M cell cycle arrest 
Other 3728 Indibulin  Microtubule destabilizer 
Other 3551 INH1  Hec1 inhibitor; causes arrest of mitosis 
Other 1097 Taxol  Promotes assembly and inhibits disassembly of microtubules 

 

  • p53

          p53 к İ ̸ transcription factor, p53 ATM, ATR, Chk1, MAPKs
          λȭ Ŀ Ȱȭ˴ϴ.

Function Cat. No. Product Name  Activity
Inhibitor 2936 NSC 66811  MDM2 inhibitor. Disrupts MDM2-p53 interaction 
Inhibitor 3843 Cyclic Pifithrin-α hydrobromide  p53 inhibitor 
Inhibitor 2653 Pifithrin-μ  Inhibitor of p53-mitochondrial binding 
Inhibitor 2443 RITA  p53-MDM2 interaction inhibitor; antitumor 
Activator 2185 NSC 146109 hydrochloride  Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
Activator 3365 Tenovin-1  Activates p53 transcriptional activity 
Activator 3356 WR 1065  p53 activator. Also ROS scavenger 
Other 3023 CP 31398 dihydrochloride  p53-stabilizing agent 

 

  • Poly(ADP-ribose) Polymerase

          PARP NAD histone ܹ ΰǴ polymerμ, DNA
          ϴ ˷ ֽϴ.

Function Cat. No. Product Name  Activity
Inhibitor 0788 3-Aminobenzamide  PARP inhibitor 
Inhibitor 3735 BYK 49187 PARP-1 and PARP-2 inhibitor 
Inhibitor 2192 4-HQN   PARP inhibitor 
Inhibitor 4514 JW 55  Tankyrase inhibitor; inhibits canonical Wnt signaling 
Inhibitor 5084 MN 64 Potent and selective tankyrase inhibitor 
Inhibitor 3736 UPF 1069  PARP-2 inhibitor 
Inhibitor 3748 XAV 939  Tankyrase inhibitor; inhibits Wnt signaling