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 제품안내  면역학   Stem Cell

Human iPSC-derived Neural Stem Cells

다양한 donor의 cell에 iPSC technology를 도입한 cerebral cortical neural stem cells (NSCs) 입니다.

Axol
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특징
  • Fully defined neural induction 조건 하에 iPSC technology를 통해 제작된 cerebral cortex 유래 neural stem cell 입니다.
  • cerebral cortical neural stem cell과 progenitor cell에서 특징적으로 보이는 PAX6, FOXG1 marker를 확인할 수 있습니다.
  • NSCs로부터 electrically active 한 cortical neuron과 in vitro functional synapses, neural circuits을 generation 할 수 있습니다.
  • 모든 cell은 1.5M cells/vial로 제공되며 구매 시 30 mL의 plating medium을 함께 드립니다. 
  • P0 state로 제공 되므로 여러 번의 expansion을 거쳐 많은 수의 cell을 확보할 수 있습니다.

 

     Phase contrast

     Axol iPSC derived Neural Stem Cells grown in Neural Expansion XF Medium with the addition of EGF and EGF2. 

    
 
     Immunofluorescence

   



1. Human iPSC-derived neural stem cells from healthy or patient donor

  • Human iPSC-Derived Neural Stem Cell Kit (ax0100)
    • 아래 리스트의 cell 중 1 vial을 선택할 수 있습니다.
    • Cell expansion과 differentiation에 필요한 reagent 및 medium이 포함되어 있습니다.
    • 2 bottles of Neural Plating-XF Medium (30 mL), SureBond Coating Solution (3 x 120 μL vials), SureBond-XF Coating Solution (1 mL), Neural Expansion-XF Medium (500 mL), SureGrowth Recombinant Human FGF2 (100 μg), SureGrowthX Recombinant Human EGF (100 μg), Unlock (25 mL), Neural Maintenance-XF Medium (500 mL) and Neural Differentiation-XF Medium (125 mL)



2. axolGEM (genetically edited model) human iPSC-derived neural stem cells

  • CRISPR/Cas9 gene editing을 통해 Parkinson's disease와 Alzheimer's disease 발병의 주요 원인으로 알려진 LRRK2와 MAPT gene을 edition한 NSCs 입니다. 
  • 별도의 cell line 제작 없이 neurodegenerative disease 연구가 가능합니다.
  • Starting Material : Fibroblasts (64 yrs, female donor)
  • Homozygous form과 Heterozygous form 중 선택하실 수 있습니다.

 

3. Neural cell culture media and reagents
  • Neural stem cell의 expansion과 differentiation에 필요한 모든 media와 reagent가 준비되어 있습니다.
  • Xeno Free condition에서 배양하실 경우, XF Medium을 사용하시면 됩니다.
  • 아래의 리스트에서 개별 선택 가능하며, 실험 종류에 따른 묶음 상품도 있습니다.







    Applications
  
   1. Transfection
   2. Neurite outgrowth
   3. Patch clamp
   4. Multi-electrode array (MEA)
   5. Transplatation

주문정보(Ordering Information)
CATNUM PRODUCT SIZE
ax0111Alzheimer's Disease Neural Stem Cells (APOE4)ea
ax0114Alzheimer's Disease Neural Stem Cells (PSEN-1 A246E)ea
ax0112Alzheimer's Disease Neural Stem Cells (PSEN-1 L286V)ea
ax0113Alzheimer's Disease Neural Stem Cells (PSEN-1 M146L)ea
ax0115Alzheimer's Disease Neural Stem Cells (PSEN-2 N141I)ea
ax0311axolGEM iPSC-Derived Neural Stem Cells LKKR2 G2019S HETea
ax0310axolGEM iPSC-Derived Neural Stem Cells LKKR2 G2019S HOMea
ax0325axolGEM iPSC-Derived Neural Stem Cells MAPT P301L HETea
ax0324axolGEM iPSC-Derived Neural Stem Cells MAPT P301L HOMea
ax0321axolGEM iPSC-Derived Neural Stem Cells MAPT R406W HETea
ax0320axolGEM iPSC-Derived Neural Stem Cells MAPT R406W HOMea
ax0323axolGEM iPSC-Derived Neural Stem Cells MAPT V337M HETea
ax0322axolGEM iPSC-Derived Neural Stem Cells MAPT V337M HOMea
ax0411Epilepsy Neural Stem Cellsea
ax0212Huntington's Disease Neural Stem Cells (male, CAG:56)ea
ax0100iPSC-derived Neural Stem Cell Kitea
ax0034-125Neural Differentiation-XF Medium125 mL
ax0030-500Neural Expansion-XF Medium500 mL
ax0032-500Neural Maintenance-XF Medium500 mL
ax0033Neural Plating-XF Medium30 mL
ax0103Neural Stem Cell Media&Reagent Bundle - Expansion and Spontaneous Differentiation (System C)ea
ax0101Neural Stem Cell Media&Reagent Bundle - Expansion and Synchronous Differentiation (System A)ea
ax0104Neural Stem Cell Media&Reagent Bundle - Spontaneous Differentiation (System D)ea
ax0102Neural Stem Cell Media&Reagent Bundle - Synchronous Differentiation (System B)ea
ax0016Neural Stem Cells (Female)ea
ax0019Neural Stem Cells (Female) ea
ax0015Neural Stem Cells (Male) ea
ax0018Neural Stem Cells (Male) ea
ax1001Neural Stem Cells (Trisomy X Mutation)ea
ax0051ReadyFect40 uL
ax0041SureBond3 x 120 uL
ax0041+SureBond + ReadySet3 x 120 uL & 2 x 10 mL
ax0041XFSureBond-XF1 mL
ax0047SureGrowth Redombinant Human FGF2100 ug
ax0047XSureGrowthX Redombinant Human EGF100 ug
ax0044Unlock25 mL
ax0044XFUnlock-XF100 mL