- 견적 및 주문
- 제품/실험 Q&A
Sensory Neuron (감각뉴런)은 감각 기관에서 받아들인 정보를 중추 신경계인 뇌와 척수로 전달하는 뉴런입니다. Pain research에 이용되는 Human iPSC-derived sensory neurons Progenitor cell을 소개합니다.
Phase contrast images show the maturation of Axol Human iPSC-Derived Sensory Neuron Progenitors
over two weeks after thawing and treatment with mitomycin C.
|Sodium ion channel expression|
Sodium channel RNA expression analysis by cDNA PCR
Axol iPSC-Derived Sensory Neuron Progenitors show RNA expression of all three voltage-gated
sodium ion channels, Nav1.7, Nav1.8 and Nav1.9.
Axol Human iPSC-Derived Sensory Neuron Progenitors express Nav1.7, a key sodium ion channel in
DRG sensory neurons that plays an important role in peripheral pain sensation.
Nav1.7 and Nav1.8 immunocytochemistry
Mature iPSC-derived sensory neurons express the sodium ion channels, Nav1.7 and Nav1.8,
and the maturation marker, doublecortin (DCX) after 6 weeks in culture.
Sodium channel–mediated response to potassium chloride
Axol iPSC-Derived Sensory Neuron Progenitors have been shown to elicit a calcium response to
the treatment of KCl at the soma signifying the presence of sodium channels.
TTX-resistant Nav1.8 and Nav1.9
Nociceptive sensory neurons are unique in that they contain voltage-gated inward current sodium
channels (Nav 1.8 and Nav 1.9) that are resistant to tetrodotoxin (TTX). The presence of these
TTX-resistant ion channels was confirmed in Axol iPSC-derived sensory neurons.
|Transient receptor potential ion channel expression|
TRPA1, TRPV1, Nav1.7 immunocytochemistry
After 5 weeks in culture, Axol hiPSC-Derived Sensory Neurons express TRPV1, TRPA1 and Nav 1.7.
Neuronal firing responses to chemical stimuli:
Wasabi (AITC), Capsaicin, Menthol
Axol Human iPSC-Derived Sensory Neuron Progenitors display electrical activity.